Polymorphisms in the vitamin D receptor gene are associated with reduced rate of sputum culture conversion in multidrug-resistant tuberculosis patients in South Africa

Vitamin D modulates the inflammatory and immune response to tuberculosis (TB) and also mediates the induction of the antimicrobial peptide cathelicidin. Deficiency of 25-hydroxyvitamin D and single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene may increase the risk of TB disea...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 7; p. e0180916
Main Authors:	Magee, Matthew J., Sun, Yan V., Brust, James C. M., Shah, N. Sarita, Ning, Yuming, Allana, Salim, Campbell, Angela, Hui, Qin, Mlisana, Koleka, Moodley, Pravi, Gandhi, Neel R.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.07.2017 Public Library of Science (PLoS)
Subjects:	25-Hydroxyvitamin D Adult Age Antiinfectives and antibacterials Biology and Life Sciences Confidence intervals Conversion Culture Deoxyribonucleic acid DNA Drug resistance Female Genomic analysis Genomics Health risks HIV HIV Infections - genetics Human immunodeficiency virus Humans Immune response Immune system Impact resistance Inflammation Male Medicine and Health Sciences Multidrug resistance Multidrug resistant organisms Patients People and Places Physical sciences Polymorphism, Single Nucleotide - genetics Populations Proportional Hazards Models Prospective Studies Receptors, Calcitriol - genetics Risk Single-nucleotide polymorphism Smear Smoking South Africa Sputum Sputum - microbiology Tuberculosis Tuberculosis, Multidrug-Resistant - genetics Vitamin D Vitamin D - analogs & derivatives Vitamin D - metabolism Vitamin D receptors Atlanta Georgia United States > US South Africa
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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