Dysconnectivity in schizophrenia: Where are we now?

The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of functional and structural neuroimaging studies have been conducted to investigate this hypothesis, across t...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Neuroscience and biobehavioral reviews Ročník 35; číslo 5; s. 1110 - 1124
Hlavní autoři:	Pettersson-Yeo, William, Allen, Paul, Benetti, Stefania, McGuire, Philip, Mechelli, Andrea
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Kidlington Elsevier 01.04.2011
Témata:	Adult and adolescent clinical studies Behavioral psychophysiology Biological and medical sciences Brain Mapping Databases, Bibliographic - statistics & numerical data Frontal Lobe - pathology Frontal Lobe - physiopathology Fundamental and applied biological sciences. Psychology Humans Medical sciences Neural Pathways - blood supply Neural Pathways - pathology Neural Pathways - physiopathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - pathology Schizophrenia - physiopathology Schizophrenic Psychology Human High risk Genetic high risk Ultra High Risk (UHR) Positron emission tomography (PET) Central nervous system Schizophrenia Review Nuclear magnetic resonance imaging Diffusion tensor imaging (DTI) Encephalon Diffusion tensor imaging Psychosis Early-onset schizophrenia (EOS) Age of onset First episode Genetics Early Connectivity First-episode (FE) Functional magnetic resonance imaging (fMRI) Positron emission tomography Functional imaging Emission tomography
ISSN:	0149-7634, 1873-7528, 1873-7528
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of functional and structural neuroimaging studies have been conducted to investigate this hypothesis, across the full course of the disorder; from people at Ultra-High-Risk of developing psychosis to patients with chronic SZ. However the results of these studies have not always been consistent, and to date, there have been no attempts to summarise the results of both methodologies in conjunction. In this article, we systematically review both the structural and functional connectivity literature in SZ. The main trends to emerge are that schizophrenia is associated with connectivity reductions, as opposed to increases, relative to healthy controls, and that this is particularly evident in the connections involving the frontal lobe. These two trends appear to apply across all stages of the disorder, and to be independent of the neuroimaging methodology employed. We discuss the potential implications of these trends, and identify possible future investigative directions.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0149-7634 1873-7528 1873-7528
DOI:	10.1016/j.neubiorev.2010.11.004