Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

V2/V3 conformational epitope antibodies that broadly neutralize HIV-1 (PG9 and PG16) have been recently described. Since an elicitation of previously known broadly neutralizing antibodies has proven elusive, the induction of antibodies with such specificity is an important goal for HIV-1 vaccine dev...

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Vydáno v:	Journal of virology Ročník 85; číslo 19; s. 9998
Hlavní autoři:	Bonsignori, Mattia, Hwang, Kwan-Ki, Chen, Xi, Tsao, Chun-Yen, Morris, Lynn, Gray, Elin, Marshall, Dawn J, Crump, John A, Kapiga, Saidi H, Sam, Noel E, Sinangil, Faruk, Pancera, Marie, Yongping, Yang, Zhang, Baoshan, Zhu, Jiang, Kwong, Peter D, O'Dell, Sijy, Mascola, John R, Wu, Lan, Nabel, Gary J, Phogat, Sanjay, Seaman, Michael S, Whitesides, John F, Moody, M Anthony, Kelsoe, Garnett, Yang, Xinzhen, Sodroski, Joseph, Shaw, George M, Montefiori, David C, Kepler, Thomas B, Tomaras, Georgia D, Alam, S Munir, Liao, Hua-Xin, Haynes, Barton F
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.10.2011
Témata:	Antibodies, Neutralizing - immunology Epitopes - genetics Epitopes - immunology Female HIV Antibodies - immunology HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV-1 - genetics HIV-1 - immunology Humans Neutralization Tests Protein Binding Surface Plasmon Resonance
ISSN:	1098-5514, 1098-5514
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