Photosensitizer effects on cancerous cells: A combined study using synchrotron infrared and fluorescence microscopies

Hypocrellin A (HA), a lipid-soluble peryloquinone derivative, isolated from natural fungus sacs of Hypocrella bambusae, has been reported to be a highly potential photosensitizer in photodynamic therapy (PDT). It has been studied increasingly because of its anticancer activities when irradiated with...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1780; no. 5; pp. 854 - 860
Main Authors:	Chio-Srichan, Sirinart, Réfrégiers, Matthieu, Jamme, Frédéric, Kascakova, Slavka, Rouam, Valérie, Dumas, Paul
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2008 Elsevier
Subjects:	Biological Physics Cancer Cancer cell Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Nucleus - radiation effects Cytoplasm - drug effects Cytoplasm - metabolism Cytoplasm - radiation effects Fluorescence HeLa Cells Humans Hypocrellin Infrared Infrared Rays Intracellular Space - chemistry Intracellular Space - metabolism Life Sciences Light Microscopy Microscopy - methods Microscopy, Fluorescence - methods Molecular Structure Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Perylene - analogs & derivatives Perylene - chemistry Perylene - metabolism Perylene - pharmacology Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - metabolism Photosensitizing Agents - pharmacology Physics Principal Component Analysis Quinones - chemistry Quinones - metabolism Quinones - pharmacology Spectrophotometry, Infrared Synchrotron Synchrotrons Photodynamic therapy Hypocrellin Infrared Microscopy Fluorescence Cancer cell Synchrotron
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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