Characteristics of the MACS/WIHS Combined Cohort Study: Opportunities for Research on Aging With HIV in the Longest US Observational Study of HIV

In 2019, the National Institutes of Health combined the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) into the MACS/WIHS Combined Cohort Study (MWCCS). In this paper, participants who made a study visit during October 2018-September 2019 (targeted for MWCCS e...

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Bibliographic Details
Published in:American journal of epidemiology Vol. 190; no. 8; p. 1457
Main Authors: D'Souza, Gypsyamber, Bhondoekhan, Fiona, Benning, Lorie, Margolick, Joseph B, Adedimeji, Adebola A, Adimora, Adaora A, Alcaide, Maria L, Cohen, Mardge H, Detels, Roger, Friedman, M Reuel, Holman, Susan, Konkle-Parker, Deborah J, Merenstein, Daniel, Ofotokun, Igho, Palella, Frank, Altekruse, Sean, Brown, Todd T, Tien, Phyllis C
Format: Journal Article
Language:English
Published: United States 01.08.2021
Subjects:
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - epidemiology
Adult
Aged
Aged, 80 and over
Aging - physiology
Anti-Retroviral Agents - therapeutic use
CD4 Lymphocyte Count
Cohort Studies
Comorbidity
Female
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - ethnology
Humans
Longitudinal Studies
Male
Middle Aged
Racial Groups
Research Design
Residence Characteristics
Risk Factors
Socioeconomic Factors
United States
Viral Load
United States
biorepositories
comorbidity
HIV
MACS/WIHS Combined Cohort Study
Multicenter AIDS Cohort Study
Women’s Interagency HIV Study
collaborative research
cohort studies
ISSN:1476-6256, 1476-6256
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Summary:In 2019, the National Institutes of Health combined the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) into the MACS/WIHS Combined Cohort Study (MWCCS). In this paper, participants who made a study visit during October 2018-September 2019 (targeted for MWCCS enrollment) are described by human immunodeficiency virus (HIV) serostatus and compared with people living with HIV (PLWH) in the United States. Participants include 2,115 women and 1,901 men with a median age of 56 years (interquartile range, 48-63); 62% are PLWH. Study sites encompass the South (18%), the Mid-Atlantic/Northeast (45%), the West Coast (22%), and the Midwest (15%). Participant race/ethnicity approximates that of PLWH throughout the United States. Longitudinal data and specimens collected for 35 years (men) and 25 years (women) were combined. Differences in data collection and coding were reviewed, and key risk factor and comorbidity data were harmonized. For example, recent use of alcohol (62%) and tobacco (28%) are common, as are dyslipidemia (64%), hypertension (56%), obesity (42%), mildly or severely impaired daily activities (31%), depressive symptoms (28%), and diabetes (22%). The MWCCS repository includes serum, plasma, peripheral blood mononuclear cells, cell pellets, urine, cervicovaginal lavage samples, oral samples, B-cell lines, stool, and semen specimens. Demographic differences between the MACS and WIHS can confound analyses by sex. The merged MWCCS is both an ongoing observational cohort study and a valuable resource for harmonized longitudinal data and specimens for HIV-related research.
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ISSN:1476-6256
1476-6256
DOI:10.1093/aje/kwab050