A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells

Oncogenic rearrangements of the anaplastic lymphoma kinase (ALK) gene, encoding a receptor type tyrosine kinase, are frequently associated with anaplastic large cell lymphomas. Such rearrangements juxtapose the intracellular domain of ALK to 5'-end sequences belonging to different genes and cre...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 277; no. 25; p. 22231
Main Authors:	Piccinini, Gina, Bacchiocchi, Roberta, Serresi, Michela, Vivani, Caterina, Rossetti, Silvia, Gennaretti, Claudia, Carbonari, Damiano, Fazioli, Francesca
Format:	Journal Article
Language:	English
Published:	United States 21.06.2002
Subjects:	3T3 Cells Adaptor Proteins, Signal Transducing Agar - pharmacology Anaplastic Lymphoma Kinase Animals Cells, Cultured DNA - biosynthesis Dose-Response Relationship, Drug Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism Fibroblasts - metabolism Glutathione Transferase - metabolism GRB2 Adaptor Protein Isoenzymes - metabolism Ligands MAP Kinase Signaling System Mice Phenotype Phospholipase C gamma Phosphorylation Precipitin Tests Protein Binding Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Proteins - metabolism Receptor Protein-Tyrosine Kinases Recombinant Fusion Proteins - metabolism Signal Transduction Transfection Type C Phospholipases - metabolism Tyrosine - metabolism Up-Regulation
ISSN:	0021-9258
Online Access:	Get more information
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