NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma

The NLRP3 (NOD‐, LRR‐, and pyrin domain‐containing protein 3) inflammasome is an immunological sensor that detects a wide range of microbial‐ and host‐derived signals. Inflammasome activation results in the release of the potent pro‐inflammatory cytokines IL‐1β and IL‐18 and triggers a form of infla...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 108; no. 3; pp. 937 - 952
Main Authors:	McKee, Chloe M., Coll, Rebecca C.
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01.09.2020
Subjects:	Animals CARD Signaling Adaptor Proteins - immunology CARD Signaling Adaptor Proteins - metabolism Caspase Activation and Recruitment Domain Cell death Gene Expression Regulation - immunology Host-Pathogen Interactions - immunology Humans IL‐1 Immunity, Innate Immunology inflammasome Inflammasomes Inflammasomes - immunology Inflammation - immunology Inflammation - therapy Inflammatory diseases Mice Microorganisms Molecular Targeted Therapy NIMA-Related Kinases - immunology NLR Family, Pyrin Domain-Containing 3 Protein - immunology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Pathogen-Associated Molecular Pattern Molecules - immunology Pathogenesis Phosphorylation Priming Protein Interaction Mapping Protein Processing, Post-Translational Proteins Pyrin Domain Pyrin protein Pyroptosis Pyroptosis - immunology therapeutics Transcription, Genetic Ubiquitination NLRP3 therapeutics IL-1 inflammasome
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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