The Discovery of Potential Repellent Compounds for Zeugodacus cucuribitae (Coquillett) from Six Non-Favored Hosts

Zeugodacus cucuribitae (Coquillett) (Z. cucuribitae) is a global extremely invasive quarantine pest which has a wide host range of fruits and vegetables. At present, there are a few control measures for Z. cucuribitae, and deltamethrin and avermectin are commonly used. Among the hosts of Z. cucuribi...

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Published in:International journal of molecular sciences Vol. 26; no. 14; p. 6556
Main Authors: Fu, Yu, Chen, Yupeng, Wang, Yani, Fu, Xinyi, Jin, Shunda, Yi, Chunyan, Bai, Xue, Lu, Youqing, Miao, Wang, Geng, Xingyu, Lu, Xianli, Yan, Rihui, Zhou, Zhongshi, Cao, Fengqin
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 08.07.2025
MDPI
Subjects:
Agricultural production
Analysis
Animals
Chemical compounds
Fruits
Genes
Genomes
Genomics
Insect Repellents - chemistry
Insect Repellents - pharmacology
Insects
Metabolism
Metabolites
Molecular Docking Simulation
Odors
Pest control
Phylogenetics
Proteins
Quarantine
Sensory perception
Toxicity
Austria
China
olfactory genes
insect repellent
molecular docking
network pharmacology
Zeugodacus cucuribitae (Coquillett)
ISSN:1422-0067, 1661-6596, 1422-0067
Online Access:Get full text
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Summary:Zeugodacus cucuribitae (Coquillett) (Z. cucuribitae) is a global extremely invasive quarantine pest which has a wide host range of fruits and vegetables. At present, there are a few control measures for Z. cucuribitae, and deltamethrin and avermectin are commonly used. Among the hosts of Z. cucuribitae, Luffa acutangular, Luffa cylindrica, Sechium edule, Brassica oleracea var. botrytis, Musa nana, and Fragaria × ananassa are non-favored hosts. However, it is still not clear why these hosts are non-favored and whether there are any repellent components of Z. cucuribitae in these hosts. In this study, the components of these six hosts were collected from the literature, and the genes of odor and chemical sensation were determined from the genome of Z. cucuribitae. After the potential relationships between these components and genes were determined by molecular docking methods, the KEGG and GO enrichment analysis of these genes was conducted, and a complex network of genes vs. components vs. Kegg pathway vs. GO terms was constructed and used to select the key components for experiments. The results show that oleanolic acid (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL), rotenone (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL), and beta-caryophyllene oxide (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL) had a significant repellent effect on Z. cucuribitae, and three components, rotenone (1 mg/mL and 0.1 mg/mL), echinocystic acid (1 mg/mL, 0.1 mg/mL, and 0.01 mg/mL), and beta-caryophyllene oxide (1 mg/mL, and 0.1 mg/mL) had significant stomach toxicity in Z. cucuribitae. Furthermore, a complex signaling pathway was built and used to predict the effect of these components on Z. cucuribitae. These components probably play roles in the neuroactive ligand–receptor interaction (ko04080) and calcium signaling (ko04020) pathways. This study provides a reference for the prevention and control of Z. cucuribitae and a scientific reference for the rapid screening and development of new pest control drugs.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms26146556