Opioid receptors: drivers to addiction?

Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid r...

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Podrobná bibliografia
Vydané v:Nature reviews. Neuroscience Ročník 19; číslo 8; s. 499 - 514
Hlavní autori: Darcq, Emmanuel, Kieffer, Brigitte Lina
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.08.2018
Nature Publishing Group
Predmet:
631/154/436/2387
631/378/1689/5
631/378/1788
631/378/2620/410
Addictions
Animal Genetics and Genomics
Animals
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain - physiopathology
Cellular signal transduction
Drug abuse
Drug addiction
Drug use
Health aspects
Humans
Molecular targeted therapy
Narcotics
Nervous system
Neural circuitry
Neurobiology
Neurons - physiology
Neurosciences
Opioid receptors (type kappa)
Opioid receptors (type mu)
Opioids
Pain
Pain - drug therapy
Psychiatric research
Public health
Receptors
Receptors, Opioid, kappa - physiology
Receptors, Opioid, mu - physiology
Review Article
Reward
Substance-Related Disorders - etiology
Substance-Related Disorders - physiopathology
Canada
ISSN:1471-003X, 1471-0048, 1471-0048, 1469-3178
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Abstract Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse. The opioid system is central to addiction. Darcq and Kieffer review the role of these receptors in the addiction neurocircuitry, ask whether opioid receptors can be targeted to kill pain without addiction and discuss studies that bridge the translational gap in the field.
AbstractList Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse.
Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse. The opioid system is central to addiction. Darcq and Kieffer review the role of these receptors in the addiction neurocircuitry, ask whether opioid receptors can be targeted to kill pain without addiction and discuss studies that bridge the translational gap in the field.
Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse. The opioid system is central to addiction. Darcq and Kieffer review the role of these receptors in the addiction neurocircuitry, ask whether opioid receptors can be targeted to kill pain without addiction and discuss studies that bridge the translational gap in the field.
Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse.Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse.
Audience Academic
Author Kieffer, Brigitte Lina
Darcq, Emmanuel
Author_xml – sequence: 1
  givenname: Emmanuel
  surname: Darcq
  fullname: Darcq, Emmanuel
  organization: Douglas Mental Health Institute, Department of Psychiatry, McGill University
– sequence: 2
  givenname: Brigitte Lina
  orcidid: 0000-0002-8809-8334
  surname: Kieffer
  fullname: Kieffer, Brigitte Lina
  email: brigitte.kieffer@douglas.mcgill.ca
  organization: Douglas Mental Health Institute, Department of Psychiatry, McGill University, Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM, Centre National de la Recherche Scientifique and University of Strasbourg
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29934561$$D View this record in MEDLINE/PubMed
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Snippet Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder....
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SubjectTerms 631/154/436/2387
631/378/1689/5
631/378/1788
631/378/2620/410
Addictions
Animal Genetics and Genomics
Animals
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain - physiopathology
Cellular signal transduction
Drug abuse
Drug addiction
Drug use
Health aspects
Humans
Molecular targeted therapy
Narcotics
Nervous system
Neural circuitry
Neurobiology
Neurons - physiology
Neurosciences
Opioid receptors (type kappa)
Opioid receptors (type mu)
Opioids
Pain
Pain - drug therapy
Psychiatric research
Public health
Receptors
Receptors, Opioid, kappa - physiology
Receptors, Opioid, mu - physiology
Review Article
Reward
Substance-Related Disorders - etiology
Substance-Related Disorders - physiopathology
Title Opioid receptors: drivers to addiction?
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