Mutational Heterogeneity in APC and KRAS Arises at the Crypt Level and Leads to Polyclonality in Early Colorectal Tumorigenesis

The majority of genomic alterations causing intratumoral heterogeneity (ITH) in colorectal cancer are thought to arise during early stages of carcinogenesis as a burst but only after truncal mutations in have expanded a single founder clone. We have investigated if the initial source of ITH is conse...

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Veröffentlicht in:	Clinical cancer research Jg. 23; H. 19; S. 5936
Hauptverfasser:	Gausachs, Mireia, Borras, Ester, Chang, Kyle, Gonzalez, Sara, Azuara, Daniel, Delgado Amador, Axel, Lopez-Doriga, Adriana, San Lucas, F Anthony, Sanjuan, Xavier, Paules, Maria J, Taggart, Melissa W, Davies, Gareth E, Ehli, Erik A, Fowler, Jerry, Moreno, Victor, Pineda, Marta, You, Y Nancy, Lynch, Patrick M, Lazaro, Conxi, Navin, Nicholas E, Scheet, Paul A, Hawk, Ernest T, Capella, Gabriel, Vilar, Eduardo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2017
Schlagworte:	Adenomatous Polyposis Coli Protein - genetics Biopsy Carcinogenesis - genetics Carcinoma Clonal Evolution - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Female Genetic Heterogeneity Genotype High-Throughput Nucleotide Sequencing Humans Male Mutation Proto-Oncogene Proteins p21(ras) - genetics
ISSN:	1078-0432, 1557-3265, 1557-3265
Online-Zugang:	Weitere Angaben
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