Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cells

Studies aimed at defining the association between host immune responses and human immunodeficiency virus (HIV) persistence during therapy are necessary to develop new strategies for cure. We performed a comprehensive assessment of ultrasensitive plasma HIV RNA levels, cell-associated HIV RNA levels...

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Vydáno v:	The Journal of infectious diseases Ročník 208; číslo 1; s. 50
Hlavní autoři:	Hatano, Hiroyu, Jain, Vivek, Hunt, Peter W, Lee, Tzong-Hae, Sinclair, Elizabeth, Do, Tri D, Hoh, Rebecca, Martin, Jeffrey N, McCune, Joseph M, Hecht, Frederick, Busch, Michael P, Deeks, Steven G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2013
Témata:	Adult Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology DNA, Viral - drug effects Female HIV - drug effects HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Humans Immunity, Cellular - drug effects Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male Middle Aged Programmed Cell Death 1 Receptor - blood Proviruses - drug effects RNA, Viral - blood D-dimer 2-LTR circles HIV ongoing viral replication raltegravir intensification
ISSN:	1537-6613, 1537-6613
On-line přístup:	Zjistit podrobnosti o přístupu
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