Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia

The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore a...

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Vydáno v:Frontiers in neurology Ročník 11; s. 609
Hlavní autoři: Meng, Xianyun, Zheng, Jianjun, Liu, Yingpeng, Yin, Yi, Hua, Kelei, Fu, Shishun, Wu, Yunfan, Jiang, Guihua
Médium: Journal Article
Jazyk:angličtina
Vydáno: Frontiers Media S.A 30.06.2020
Témata:
dynamic amplitude of low frequency fluctuation
functional magnetic resonance imaging
intrinsic brain activity
Neurology
primary insomnia
temporal variability
ISSN:1664-2295, 1664-2295
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Shrnutí:The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI.The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI.
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Reviewed by: Arturo Garay, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC), Argentina; Axel Steiger, Ludwig Maximilian University of Munich, Germany
Edited by: Ingo Fietze, Charité – Universitätsmedizin Berlin, Germany
This article was submitted to Sleep Disorders, a section of the journal Frontiers in Neurology
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.00609