Effect of Acetylcholinesterase Inhibitors on Cerebral Perfusion and Cognition: A Systematic Review
Perfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact of perfusion modifiers should be evaluated. In this systematic review, the impact of acute and chronic intake of four acetylcho...
Saved in:
| Published in: | Journal of Alzheimer's disease Vol. 93; no. 4; p. 1211 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Netherlands
13.06.2023
|
| Subjects: | |
| ISSN: | 1875-8908, 1875-8908 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Perfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact of perfusion modifiers should be evaluated.
In this systematic review, the impact of acute and chronic intake of four acetylcholinesterase inhibitors (AChEIs) on cerebral perfusion in adults was investigated: physostigmine, donepezil, galantamine, and rivastigmine.
Chronic AChEI treatment results in an increase of cerebral perfusion in treatment-responsive patients with Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease dementia in the frontal, parietal, temporal, and occipital lobes, as well as the cingulate gyrus. These effects appear to be temporary, dose-related, and consistent across populations and different AChEI types. On the contrary, further perfusion decline was reported in patients not receiving AChEIs or not responding to the treatment.
AChEIs appear to be a potential perfusion modifier in neurodegenerative patients. More research focused on quantitative perfusion in both patients with and without a cholinergic deficit is needed to draw conclusions on whether AChEI intake should be considered when analyzing perfusion data. |
|---|---|
| AbstractList | Perfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact of perfusion modifiers should be evaluated.
In this systematic review, the impact of acute and chronic intake of four acetylcholinesterase inhibitors (AChEIs) on cerebral perfusion in adults was investigated: physostigmine, donepezil, galantamine, and rivastigmine.
Chronic AChEI treatment results in an increase of cerebral perfusion in treatment-responsive patients with Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease dementia in the frontal, parietal, temporal, and occipital lobes, as well as the cingulate gyrus. These effects appear to be temporary, dose-related, and consistent across populations and different AChEI types. On the contrary, further perfusion decline was reported in patients not receiving AChEIs or not responding to the treatment.
AChEIs appear to be a potential perfusion modifier in neurodegenerative patients. More research focused on quantitative perfusion in both patients with and without a cholinergic deficit is needed to draw conclusions on whether AChEI intake should be considered when analyzing perfusion data. Perfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact of perfusion modifiers should be evaluated.BACKGROUNDPerfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived parameters, the impact of perfusion modifiers should be evaluated.In this systematic review, the impact of acute and chronic intake of four acetylcholinesterase inhibitors (AChEIs) on cerebral perfusion in adults was investigated: physostigmine, donepezil, galantamine, and rivastigmine.OBJECTIVEIn this systematic review, the impact of acute and chronic intake of four acetylcholinesterase inhibitors (AChEIs) on cerebral perfusion in adults was investigated: physostigmine, donepezil, galantamine, and rivastigmine.Chronic AChEI treatment results in an increase of cerebral perfusion in treatment-responsive patients with Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease dementia in the frontal, parietal, temporal, and occipital lobes, as well as the cingulate gyrus. These effects appear to be temporary, dose-related, and consistent across populations and different AChEI types. On the contrary, further perfusion decline was reported in patients not receiving AChEIs or not responding to the treatment.RESULTSChronic AChEI treatment results in an increase of cerebral perfusion in treatment-responsive patients with Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease dementia in the frontal, parietal, temporal, and occipital lobes, as well as the cingulate gyrus. These effects appear to be temporary, dose-related, and consistent across populations and different AChEI types. On the contrary, further perfusion decline was reported in patients not receiving AChEIs or not responding to the treatment.AChEIs appear to be a potential perfusion modifier in neurodegenerative patients. More research focused on quantitative perfusion in both patients with and without a cholinergic deficit is needed to draw conclusions on whether AChEI intake should be considered when analyzing perfusion data.CONCLUSIONAChEIs appear to be a potential perfusion modifier in neurodegenerative patients. More research focused on quantitative perfusion in both patients with and without a cholinergic deficit is needed to draw conclusions on whether AChEI intake should be considered when analyzing perfusion data. |
| Author | Clement, Patricia Beun, Soetkin Achten, Eric Moyaert, Paulien |
| Author_xml | – sequence: 1 givenname: Paulien surname: Moyaert fullname: Moyaert, Paulien organization: Lawson Health Research Institute, London, ON, Canada – sequence: 2 givenname: Soetkin surname: Beun fullname: Beun, Soetkin organization: Department of Diagnostic Sciences, Ghent University, Ghent, Belgium – sequence: 3 givenname: Eric surname: Achten fullname: Achten, Eric organization: Department of Diagnostic Sciences, Ghent University, Ghent, Belgium – sequence: 4 givenname: Patricia surname: Clement fullname: Clement, Patricia organization: Department of Medical Imaging, Ghent University Hospital, Ghent, Belgium |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37182871$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUEtLxDAYDKK4D734AyRHL9U8mk3qrdRVVxYUH-eStF_cSJuuSavsv7fgCp5mvmFm4JsZOvSdB4TOKLnkjPOrh_wmYYxSJg7QlCopEpURdfiPT9Asxg9CCCeZPEYTLqliStIpMktroepxZ3FeQb9rqk3XOA-xh6Aj4JXfOOP6LkTceVxAABN0g58g2CG6UdK-xkX37l0_Xtc4xy-7Mdvq3lX4Gb4cfJ-gI6ubCKd7nKO32-VrcZ-sH-9WRb5OqpRnfaIW3LKMKw6EQC2pESarGQgpUq1SSVJdG2aFrYFn0lRUMENYSrWthZXCSDZHF7-929B9DuMHZetiBU2jPXRDLJmiXCm5oIvRer63DqaFutwG1-qwK_92YT_NyGYD |
| CitedBy_id | crossref_primary_10_1016_j_nbd_2024_106406 crossref_primary_10_1093_brain_awae156 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.3233/JAD-221125 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 1875-8908 |
| ExternalDocumentID | 37182871 |
| Genre | Systematic Review |
| GroupedDBID | --- 0R~ 0VX 29J 36B 4.4 53G 5GY AAFNC AAQXI AAWTL ABDBF ABIVO ABJNI ABUBZ ABUJY ACGFS ACPQW ACPRK ACUHS ADZMO AELRD AENEX AFRAH AFRHK AGIAB AHDMH ALMA_UNASSIGNED_HOLDINGS CAG CGR COF CUY CVF DU5 EAD EAP EBS ECM EIF EJD EMB EMK EMOBN ESX F5P HZ~ IL9 IOS J8X MET MIO MV1 NGNOM NPM O9- P2P Q1R S70 SAUOL SFC SV3 TUS VUG 7X8 AAFWJ AAPII ABJZC AIRSE AJGYC AJNRN ARTOV H13 SCNPE |
| ID | FETCH-LOGICAL-c439t-863f29383e00ed71b5b9d2e5754a84704adb2f5fde397bc152b0241afd5f75b72 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 4 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001006111900002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1875-8908 |
| IngestDate | Sun Sep 28 00:34:41 EDT 2025 Wed Feb 19 02:22:50 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | alzheimer’s disease Acetylcholinesterase inhibitors diagnosis perfusion biological variation |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c439t-863f29383e00ed71b5b9d2e5754a84704adb2f5fde397bc152b0241afd5f75b72 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
| OpenAccessLink | https://content.iospress.com:443/download/journal-of-alzheimers-disease/jad221125?id=journal-of-alzheimers-disease%2Fjad221125 |
| PMID | 37182871 |
| PQID | 2813887616 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2813887616 pubmed_primary_37182871 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-06-13 |
| PublicationDateYYYYMMDD | 2023-06-13 |
| PublicationDate_xml | – month: 06 year: 2023 text: 2023-06-13 day: 13 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Journal of Alzheimer's disease |
| PublicationTitleAlternate | J Alzheimers Dis |
| PublicationYear | 2023 |
| SSID | ssj0003097 |
| Score | 2.4108584 |
| SecondaryResourceType | review_article |
| Snippet | Perfusion imaging has the potential to identify neurodegenerative disorders in a preclinical stage. However, to correctly interpret perfusion-derived... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1211 |
| SubjectTerms | Acetylcholinesterase Alzheimer Disease - drug therapy Cerebrovascular Circulation Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Cognition Dementia - drug therapy Galantamine - pharmacology Galantamine - therapeutic use Humans Indans - therapeutic use Parkinson Disease - drug therapy Perfusion Phenylcarbamates - therapeutic use Piperidines - therapeutic use Rivastigmine - therapeutic use |
| Title | Effect of Acetylcholinesterase Inhibitors on Cerebral Perfusion and Cognition: A Systematic Review |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37182871 https://www.proquest.com/docview/2813887616 |
| Volume | 93 |
| WOSCitedRecordID | wos001006111900002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA7qevDiA1_riwhew7ZJs029SFkVFV0WfLC3kjQJLizput0V_PdO2q57EgQvvbWUyWTmm8zk-xC6MNTzSIU5oVIqErFIEiF5QuJA5twjjqS6X_H2GPf7YjhMBs2BW9mMVS5iYhWodZH7M_IOFSGDDdENu1eTD-JVo3x3tZHQWEUtBh_2Xh0Pl2zhLKjFVQCTE5EEoqYnZZSxzkN6TSgUP5T_Di2rFHO79d-f20abDbjEae0NO2jFuF2kaoJiXFic5mb2NfYBzw-7-7vHpcH37n2kRl50BxcO98zUt5LHeGCmdu6P0rB0GvfqKaPCXeIUP_-wP-O6tbCHXm9vXnp3pFFWIDkAkBkRXWYhzwtmgsDoOFRcJZoagG6RhHQVRFIrarnVBlZL5ZDjFeTyUFrNbcxVTPfRmiucOURYiCTiOU8YlOgAxnQSRkoYcA1Y6SAUqo3OFybLwHN9O0I6U8zLbGm0Njqo7Z5NaoqNjEHK9LXc0R_ePkYbXgPez2-F7AS1LOxbc4rW88_ZqJyeVS4Bz_7g6RuOMMD7 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effect+of+Acetylcholinesterase+Inhibitors+on+Cerebral+Perfusion+and+Cognition%3A+A+Systematic+Review&rft.jtitle=Journal+of+Alzheimer%27s+disease&rft.au=Moyaert%2C+Paulien&rft.au=Beun%2C+Soetkin&rft.au=Achten%2C+Eric&rft.au=Clement%2C+Patricia&rft.date=2023-06-13&rft.issn=1875-8908&rft.eissn=1875-8908&rft.volume=93&rft.issue=4&rft.spage=1211&rft_id=info:doi/10.3233%2FJAD-221125&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1875-8908&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1875-8908&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1875-8908&client=summon |