Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in lip...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine Jg. 215; H. 6; S. 1571
Hauptverfasser:	Pardi, Norbert, Hogan, Michael J, Naradikian, Martin S, Parkhouse, Kaela, Cain, Derek W, Jones, Letitia, Moody, M Anthony, Verkerke, Hans P, Myles, Arpita, Willis, Elinor, LaBranche, Celia C, Montefiori, David C, Lobby, Jenna L, Saunders, Kevin O, Liao, Hua-Xin, Korber, Bette T, Sutherland, Laura L, Scearce, Richard M, Hraber, Peter T, Tombácz, István, Muramatsu, Hiromi, Ni, Houping, Balikov, Daniel A, Li, Charles, Mui, Barbara L, Tam, Ying K, Krammer, Florian, Karikó, Katalin, Polacino, Patricia, Eisenlohr, Laurence C, Madden, Thomas D, Hope, Michael J, Lewis, Mark G, Lee, Kelly K, Hu, Shiu-Lok, Hensley, Scott E, Cancro, Michael P, Haynes, Barton F, Weissman, Drew
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.06.2018
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Antibodies, Neutralizing - immunology Antibody Formation - immunology Antigens - metabolism B-Lymphocytes - immunology Germinal Center - cytology Lipids - chemistry Macaca mulatta Nanoparticles - chemistry Nucleosides - metabolism Protein Subunits - metabolism RNA, Messenger - metabolism T-Lymphocytes, Helper-Inducer - immunology Time Factors Vaccination Vaccines, Subunit - immunology
ISSN:	1540-9538, 1540-9538
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!