The Role of the AGPAT2 Gene in Adipose Tissue Biology and Congenital Generalized Lipodystrophy Pathophysiology

1-Acylglycerol-3-phosphate O-acyltransferase (1-AGPAT) is an enzyme family composed of 11 isoforms. Notably, 1-AGPAT 2, the most studied isoform since its discovery, is a critical enzyme in the triglyceride synthesis pathway, converting lysophosphatidic acid to phosphatidic acid. In addition, AGPAT2...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 26; no. 11; p. 5416
Main Authors:	de Melo, Maria Eduarda Cardoso, da Silva, Letícia Marques Gomes, Cavalcante, Ana Carolina Costa, Lima, Josivan Gomes, Campos, Julliane Tamara Araújo de Melo
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 05.06.2025 MDPI
Subjects:	1-Acylglycerol-3-Phosphate O-Acyltransferase - chemistry 1-Acylglycerol-3-Phosphate O-Acyltransferase - genetics 1-Acylglycerol-3-Phosphate O-Acyltransferase - metabolism Adipocytes Adipose Tissue - metabolism Adipose Tissue - pathology Adipose tissues Amino acids Biosynthesis Cancer Congenital diseases Development and progression Enzymes Fatty acids Gene expression Genes Genetic disorders Genomes Genotype & phenotype Humans Insulin resistance Lipids Lipodystrophy Lipodystrophy, Congenital Generalized - genetics Lipodystrophy, Congenital Generalized - metabolism Lipodystrophy, Congenital Generalized - pathology Lipodystrophy, Congenital Generalized - physiopathology Liver Medical research Medicine, Experimental Metabolism Mutation Pathogenesis Phosphates Physiology Proteins Review Signal transduction Software Triglycerides Type 2 diabetes Brazil adipogenesis white adipose tissue genetic lipodystrophy lipid metabolism
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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