Effects of Hypericum scabrum extract on learning and memory and oxidant/antioxidant status in rats fed a long-term high-fat diet

A high-fat diet (HFD) causes deficits in learning and memory by increasing oxidative stress. Antioxidants are known to improve learning and memory. Since Hypericum scabrum (H. scabrum) extract is rich in antioxidants, the aim of this study was to investigate the effects of the administration of H. s...

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Bibliographic Details
Published in:Metabolic brain disease Vol. 32; no. 4; pp. 1255 - 1265
Main Authors: Ganji, Ahmad, Salehi, Iraj, Nazari, Masoumeh, Taheri, Masoumeh, Komaki, Alireza
Format: Journal Article
Language:English
Published: New York Springer US 01.08.2017
Springer Nature B.V
Subjects:
Animals
Antioxidants
Antioxidants - pharmacology
Aversion learning
Avoidance
Avoidance learning
Avoidance Learning - drug effects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Body Weight - drug effects
Catalase
Catalase - blood
Diet
Diet, High-Fat
High fat diet
Hypericum
Learning
Lipid Peroxidation - drug effects
Locomotor activity
Male
Malondialdehyde
Malondialdehyde - blood
Memory
Memory - drug effects
Metabolic Diseases
Motor Activity - drug effects
Neurology
Neurosciences
Object recognition
Oncology
Original Article
Oxidative stress
Oxidative Stress - drug effects
Pattern recognition
Plant Extracts - pharmacology
Rats
Rats, Wistar
Recognition (Psychology) - drug effects
Serial learning
Weighing
Catalase
Memory
High-fat diet
Passive avoidance
Malondialdehyde
Hypericum Scabrum
ISSN:0885-7490, 1573-7365, 1573-7365
Online Access:Get full text
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Summary:A high-fat diet (HFD) causes deficits in learning and memory by increasing oxidative stress. Antioxidants are known to improve learning and memory. Since Hypericum scabrum (H. scabrum) extract is rich in antioxidants, the aim of this study was to investigate the effects of the administration of H. scabrum extract on passive avoidance learning (PAL), novel object recognition (NOR), and locomotor activity in male rats on a HFD. Fifty-four male Wistar rats (weighing 220 ± 10 g) were divided into the following six groups: (1) Control (standard diet), (2) Ext100 (standard diet supplemented with 100 mg/kg extract once/day), (3) Ext300 (standard diet supplemented with 300 mg/kg extract once/day), (4) HFD (high-fat diet), (5) HFD + Ext100, and (6) HFD + Ext300. Rats in these groups were maintained on their respective diets for 3 months. In the PAL test, the step-through latencies in the retention test (STLr) were significantly higher in the HFD + extract group than in the HFD group. The time spent in the dark compartment (TDC) was significantly lesser and the time spent in exploring the novel object was significantly greater in the HFD + extract group than in the HFD group. In the HFD-fed rats, the activity of catalase had significantly decreased, and level of malondialdehyde had significantly increased; H. scabrum extract administration significantly reversed these changes. In conclusion, these results suggested that the administration of H. scabrum extract and its strong antioxidant properties enhanced learning and memory and reversed the memory impairment induced by chronic HFD consumption.
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ISSN:0885-7490
1573-7365
1573-7365
DOI:10.1007/s11011-017-0022-4