Effects of Hypericum scabrum extract on learning and memory and oxidant/antioxidant status in rats fed a long-term high-fat diet

A high-fat diet (HFD) causes deficits in learning and memory by increasing oxidative stress. Antioxidants are known to improve learning and memory. Since Hypericum scabrum (H. scabrum) extract is rich in antioxidants, the aim of this study was to investigate the effects of the administration of H. s...

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Vydáno v:	Metabolic brain disease Ročník 32; číslo 4; s. 1255 - 1265
Hlavní autoři:	Ganji, Ahmad, Salehi, Iraj, Nazari, Masoumeh, Taheri, Masoumeh, Komaki, Alireza
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer US 01.08.2017 Springer Nature B.V
Témata:	Animals Antioxidants Antioxidants - pharmacology Aversion learning Avoidance Avoidance learning Avoidance Learning - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Body Weight - drug effects Catalase Catalase - blood Diet Diet, High-Fat High fat diet Hypericum Learning Lipid Peroxidation - drug effects Locomotor activity Male Malondialdehyde Malondialdehyde - blood Memory Memory - drug effects Metabolic Diseases Motor Activity - drug effects Neurology Neurosciences Object recognition Oncology Original Article Oxidative stress Oxidative Stress - drug effects Pattern recognition Plant Extracts - pharmacology Rats Rats, Wistar Recognition (Psychology) - drug effects Serial learning Weighing Catalase Memory High-fat diet Passive avoidance Malondialdehyde Hypericum Scabrum
ISSN:	0885-7490, 1573-7365, 1573-7365
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Shrnutí:	A high-fat diet (HFD) causes deficits in learning and memory by increasing oxidative stress. Antioxidants are known to improve learning and memory. Since Hypericum scabrum (H. scabrum) extract is rich in antioxidants, the aim of this study was to investigate the effects of the administration of H. scabrum extract on passive avoidance learning (PAL), novel object recognition (NOR), and locomotor activity in male rats on a HFD. Fifty-four male Wistar rats (weighing 220 ± 10 g) were divided into the following six groups: (1) Control (standard diet), (2) Ext100 (standard diet supplemented with 100 mg/kg extract once/day), (3) Ext300 (standard diet supplemented with 300 mg/kg extract once/day), (4) HFD (high-fat diet), (5) HFD + Ext100, and (6) HFD + Ext300. Rats in these groups were maintained on their respective diets for 3 months. In the PAL test, the step-through latencies in the retention test (STLr) were significantly higher in the HFD + extract group than in the HFD group. The time spent in the dark compartment (TDC) was significantly lesser and the time spent in exploring the novel object was significantly greater in the HFD + extract group than in the HFD group. In the HFD-fed rats, the activity of catalase had significantly decreased, and level of malondialdehyde had significantly increased; H. scabrum extract administration significantly reversed these changes. In conclusion, these results suggested that the administration of H. scabrum extract and its strong antioxidant properties enhanced learning and memory and reversed the memory impairment induced by chronic HFD consumption.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0885-7490 1573-7365 1573-7365
DOI:	10.1007/s11011-017-0022-4