Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling

Physical exercise is an effective therapy for improving stroke recovery. However, the exact underlying molecular mechanisms of exercise-enhanced neuronal repair remain unclear. As exercise affects the immune system in healthy individuals, and the immune system in turn influences recovery after strok...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 8928 - 16
Main Authors:	Schmidt-Pogoda, A., Ruck, T., Strecker, JK, Hoppen, M., Fazio, L., Vinnenberg, L., Maus, B., Wachsmuth, L., Cerina, M., Diederich, K., Lichtenberg, S., Abberger, H., Haertel, LAL, Schafflick, D., Meyer zu Hörste, G., Herrmann, AM, Hundehege, P., Narayanan, V., Nelke, C., Kruithoff, K., Bosbach, J., Vicari, E., Ramcke, T., Beuker, C., Hadaschik, E., Budde, T., Faber, C., Wiendl, H., Hansen, W., Meuth, SG, Minnerup, J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.10.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/106 13/31 13/51 14/19 14/34 14/35 14/63 38/77 59 59/57 64/110 692/617/375/380 692/617/375/534 Adhesives Animals Asymmetry Brain - pathology Brain - physiopathology Brain Ischemia - immunology Brain Ischemia - physiopathology Cytokines Disease Models, Animal Exercise Humanities and Social Sciences Immune system Immunoregulation Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Interleukins Ischemia Ischemic Stroke - immunology Ischemic Stroke - physiopathology Lymphocytes Lymphocytes T Magnetic resonance imaging Male Mice Mice, Inbred C57BL Molecular modelling multidisciplinary Neural networks Neurons - metabolism Neurons - physiology Neuroplasticity Physical Conditioning, Animal - physiology Physical exercise Recovery Recovery of Function Regeneration Science Science (multidisciplinary) Signal Transduction Stroke Stroke - immunology Stroke - physiopathology Stroke Rehabilitation - methods Structure-function relationships T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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