Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway Activation

Retinoid X-receptors (RXRs) are members of the ligand-dependent transcription factor family of nuclear receptors that have gained recent research focus as potential targets for neurodegenerative disorders. Bexarotene is an RXR pharmacological agonist that is shown to be neuroprotective through its e...

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Veröffentlicht in:	Molecular neurobiology Jg. 55; H. 12; S. 9043 - 9056
Hauptverfasser:	Dheer, Yogita, Chitranshi, Nitin, Gupta, Veer, Abbasi, Mojdeh, Mirzaei, Mehdi, You, Yuyi, Chung, Roger, Graham, Stuart L., Gupta, Vivek
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.12.2018 Springer Nature B.V
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Animals Apoptosis Apoptosis - drug effects Bad protein bcl-Associated Death Protein - metabolism Bexarotene - pharmacology Bexarotene - therapeutic use Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor Cell Survival - drug effects Disease Models, Animal Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Glial cells Heat shock proteins Humans Immunofluorescence Isoforms Male Mice, Inbred C57BL Neurobiology Neuroblasts Neurodegenerative diseases Neurology Neuroprotection Neuroprotection - drug effects Neurosciences Neurotoxicity Neurotoxicity Syndromes - drug therapy Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Nuclear receptors Receptor, trkB - metabolism Retinoid X receptors Retinoid X Receptors - metabolism Signal transduction Stress response Therapeutic applications Therapeutic targets TrkB receptors Up-Regulation - drug effects Western blotting ER stress Retinoid-X-receptor Bexarotene TrkB Amyloid beta
ISSN:	0893-7648, 1559-1182, 1559-1182
Online-Zugang:	Volltext
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