Troponin, NT-proBNP and postoperative atrial fibrillation in a prospective cohort undergoing coronary artery bypass surgery

Troponin and N-terminal pro B-type natriuretic peptide (NT-proBNP) are biomarkers of cardiac damage and myocyte stretch. The existing evidence on the predictive value of preoperative high-sensitive Troponin and NT-proBNP concentration for the onset of postoperative atrial fibrillation (POAF) is inco...

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Bibliographic Details
Published in:Scientific reports Vol. 15; no. 1; pp. 28885 - 9
Main Authors: Ohlrogge, Amelie H., Seum, Ferdinand, Ruhland, Korbinian, Ojeda, Francisco M., Börschel, Christin S., Pecha, Simon, Blankenberg, Stefan, Zeller, Tanja, Schnabel, Renate B.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 07.08.2025
Nature Publishing Group
Nature Portfolio
Subjects:
692/4019/592/75/29/1309
692/53/2423
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - diagnosis
Atrial Fibrillation - etiology
Biomarker
Biomarkers
Biomarkers - blood
Body mass index
Brain natriuretic peptide
Bypass
Cardiac arrhythmia
Cholesterol
Cohort analysis
Coronary artery
Coronary Artery Bypass - adverse effects
Diabetes
Electrocardiography
Electronic health records
Female
Fibrillation
Heart failure
Heart surgery
High-sensitive troponin I
High-sensitive troponin T
Humanities and Social Sciences
Humans
Hypertension
Male
Medical records
Middle Aged
Mortality
multidisciplinary
Myocytes
Natriuretic Peptide, Brain - blood
NT-proBNP
Observational studies
Patients
Peptide Fragments - blood
Peptides
Postoperative atrial fibrillation
Postoperative Complications - blood
Postoperative Complications - etiology
Prospective Studies
Regression analysis
Risk assessment
Risk Factors
Risk prediction
Science
Science (multidisciplinary)
Statistical analysis
Troponin
Troponin - blood
Germany
Risk prediction
High-sensitive troponin T
Biomarker
NT-proBNP
Postoperative atrial fibrillation
High-sensitive troponin I
ISSN:2045-2322, 2045-2322
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Summary:Troponin and N-terminal pro B-type natriuretic peptide (NT-proBNP) are biomarkers of cardiac damage and myocyte stretch. The existing evidence on the predictive value of preoperative high-sensitive Troponin and NT-proBNP concentration for the onset of postoperative atrial fibrillation (POAF) is inconsistent. Therefore, we aimed to assess these biomarkers as predictors for POAF in a prospective observational cohort study of patients without atrial fibrillation undergoing coronary artery bypass graft surgery (CABG). We analysed 423 patients with a median age of 66.3 years, 15.1% were women. About a third of these patients ( N  = 135, 32.4%) developed POAF. The median concentration of (25th, 75th percentile) high-sensitive Troponin at baseline was 11.8 (5.6, 42.7) ng/l in the POAF group and 11.4 (5.2, 37.0) ng/l in the group without POAF, median NT-proBNP was 255 (131, 621) ng/l in the POAF group and 184 (91, 497) in the group without POAF. In uni- and multivariable analyses neither biomarker showed statistically significant associations with POAF. These findings add further neutral data to the inconsistent results found in the current literature and mandate the search for better clinical or biomarker information to assess the risk of this common complication of CABG surgery.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-12122-3