Phylogenetic Characterizations of Highly Mutated EV-B106 Recombinants Showing Extensive Genetic Exchanges with Other EV-B in Xinjiang, China

Human enterovirus B106 (EV-B106) is a new member of the enterovirus B species. To date, only three nucleotide sequences of EV-B106 have been published, and only one full-length genome sequence (the Yunnan strain 148/YN/CHN/12) is available in the GenBank database. In this study, we conducted phyloge...

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Vydáno v:Scientific reports Ročník 7; číslo 1; s. 43080
Hlavní autoři: Song, Yang, Zhang, Yong, Fan, Qin, Cui, Hui, Yan, Dongmei, Zhu, Shuangli, Tang, Haishu, Sun, Qiang, Wang, Dongyan, Xu, Wenbo
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 23.02.2017
Nature Publishing Group
Témata:
45/77
45/90
631/181/735
692/308/174
692/699/255/2514
Amino acids
Antibodies
Epidemiology
Genomes
Humanities and Social Sciences
multidisciplinary
Mutagenicity
Nucleotide sequence
Phylogenetics
Phylogeny
Population studies
Recombinants
Recombination
Science
Serology
Temperature effects
China
ISSN:2045-2322, 2045-2322
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Shrnutí:Human enterovirus B106 (EV-B106) is a new member of the enterovirus B species. To date, only three nucleotide sequences of EV-B106 have been published, and only one full-length genome sequence (the Yunnan strain 148/YN/CHN/12) is available in the GenBank database. In this study, we conducted phylogenetic characterisation of four EV-B106 strains isolated in Xinjiang, China. Pairwise comparisons of the nucleotide sequences and the deduced amino acid sequences revealed that the four Xinjiang EV-B106 strains had only 80.5–80.8% nucleotide identity and 95.4–97.3% amino acid identity with the Yunnan EV-B106 strain, indicating high mutagenicity. Similarity plots and bootscanning analyses revealed that frequent intertypic recombination occurred in all four Xinjiang EV-B106 strains in the non-structural region. These four strains may share a donor sequence with the EV-B85 strain, which circulated in Xinjiang in 2011, indicating extensive genetic exchanges between these strains. All Xinjiang EV-B106 strains were temperature-sensitive. An antibody seroprevalence study against EV-B106 in two Xinjiang prefectures also showed low titres of neutralizing antibodies, suggesting limited exposure and transmission in the population. This study contributes the whole genome sequences of EV-B106 to the GenBank database and provides valuable information regarding the molecular epidemiology of EV-B106 in China.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep43080