Imaging cervical cytology with scanning near-field optical microscopy (SNOM) coupled with an IR-FEL
Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that scanning near-field optical microscopy, in combinat...
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| Vydané v: | Scientific reports Ročník 6; číslo 1; s. 29494 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , |
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| Jazyk: | English |
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Nature Publishing Group UK
12.07.2016
Nature Publishing Group |
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| ISSN: | 2045-2322, 2045-2322 |
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| Abstract | Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that scanning near-field optical microscopy, in combination with an infrared free electron laser (SNOM-IR-FEL), is able to distinguish between normal and squamous low-grade and high-grade dyskaryosis and between normal and mixed squamous/glandular pre-invasive and adenocarcinoma cervical lesions, at designated wavelengths associated with DNA, Amide I/II and lipids. These findings evidence the promise of the SNOM-IR-FEL technique in obtaining chemical information relevant to the detection of cervical cell abnormalities and cancer diagnosis at spatial resolutions below the diffraction limit (≥0.2 μm). We compare these results with analyses following attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy; although this latter approach has been demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by a spatial resolution of ~3 μm to 30 μm due to the optical diffraction limit. |
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| AbstractList | Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that scanning near-field optical microscopy, in combination with an infrared free electron laser (SNOM-IR-FEL), is able to distinguish between normal and squamous low-grade and high-grade dyskaryosis and between normal and mixed squamous/glandular pre-invasive and adenocarcinoma cervical lesions, at designated wavelengths associated with DNA, Amide I/II and lipids. These findings evidence the promise of the SNOM-IR-FEL technique in obtaining chemical information relevant to the detection of cervical cell abnormalities and cancer diagnosis at spatial resolutions below the diffraction limit (≥0.2 μm). We compare these results with analyses following attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy; although this latter approach has been demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by a spatial resolution of ~3 μm to 30 μm due to the optical diffraction limit. Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that scanning near-field optical microscopy, in combination with an infrared free electron laser (SNOM-IR-FEL), is able to distinguish between normal and squamous low-grade and high-grade dyskaryosis, and between normal and mixed squamous/glandular pre-invasive and adenocarcinoma cervical lesions, at designated wavelengths associated with DNA, Amide I/II and lipids. These findings evidence the promise of the SNOM-IR-FEL technique in obtaining chemical information relevant to the detection of cervical cell abnormalities and cancer diagnosis at spatial resolutions below the diffraction limit (≥0.2 μm). We compare these results with analyses following attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy; although this latter approach has been demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by a spatial resolution of ~3 μm to 30 μm due to the optical diffraction limit.Cervical cancer remains a major cause of morbidity and mortality among women, especially in the developing world. Increased synthesis of proteins, lipids and nucleic acids is a pre-condition for the rapid proliferation of cancer cells. We show that scanning near-field optical microscopy, in combination with an infrared free electron laser (SNOM-IR-FEL), is able to distinguish between normal and squamous low-grade and high-grade dyskaryosis, and between normal and mixed squamous/glandular pre-invasive and adenocarcinoma cervical lesions, at designated wavelengths associated with DNA, Amide I/II and lipids. These findings evidence the promise of the SNOM-IR-FEL technique in obtaining chemical information relevant to the detection of cervical cell abnormalities and cancer diagnosis at spatial resolutions below the diffraction limit (≥0.2 μm). We compare these results with analyses following attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy; although this latter approach has been demonstrated to detect underlying cervical atypia missed by conventional cytology, it is limited by a spatial resolution of ~3 μm to 30 μm due to the optical diffraction limit. |
| ArticleNumber | 29494 |
| Author | Halliwell, Diane E. Weightman, Peter Martin, Francis L. Kyrgiou, Maria Siggel-King, Michele R. F. Martin, David S. Craig, Tim Paraskevaidis, Evangelos Theophilou, Georgios Trevisan, Julio Heys, Kelly A. Martin-Hirsch, Pierre L. Mitra, Anita Cricenti, Antonio Luce, Marco Lima, Kássio M. G. Ingham, James Morais, Camilo L. M. |
| Author_xml | – sequence: 1 givenname: Diane E. surname: Halliwell fullname: Halliwell, Diane E. organization: Centre for Biophotonics, LEC, Lancaster University – sequence: 2 givenname: Camilo L. M. surname: Morais fullname: Morais, Camilo L. M. organization: Biological Chemistry and Chemometrics, Institute of Chemistry, Federal University of Rio Grande do Norte – sequence: 3 givenname: Kássio M. G. surname: Lima fullname: Lima, Kássio M. G. organization: Biological Chemistry and Chemometrics, Institute of Chemistry, Federal University of Rio Grande do Norte – sequence: 4 givenname: Julio surname: Trevisan fullname: Trevisan, Julio organization: Institute of Astronomy, Geophysics and Atmospheric Sciences, University of São Paulo – sequence: 5 givenname: Michele R. F. surname: Siggel-King fullname: Siggel-King, Michele R. F. organization: Department of Physics, University of Liverpool, Oliver Lodge Building, Accelerator Science and Technology Centre (ASTEC), STFC Daresbury Laboratory – sequence: 6 givenname: Tim surname: Craig fullname: Craig, Tim organization: Department of Physics, University of Liverpool, Oliver Lodge Building – sequence: 7 givenname: James surname: Ingham fullname: Ingham, James organization: Department of Physics, University of Liverpool, Oliver Lodge Building – sequence: 8 givenname: David S. surname: Martin fullname: Martin, David S. organization: Department of Physics, University of Liverpool, Oliver Lodge Building – sequence: 9 givenname: Kelly A. surname: Heys fullname: Heys, Kelly A. organization: Centre for Biophotonics, LEC, Lancaster University – sequence: 10 givenname: Maria surname: Kyrgiou fullname: Kyrgiou, Maria organization: Department of Surgery & Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, West London Gynaecological Cancer Centre, Imperial College NHS Healthcare – sequence: 11 givenname: Anita surname: Mitra fullname: Mitra, Anita organization: Department of Surgery & Cancer, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, West London Gynaecological Cancer Centre, Imperial College NHS Healthcare – sequence: 12 givenname: Evangelos surname: Paraskevaidis fullname: Paraskevaidis, Evangelos organization: Department of Obstetrics and Gynaecology, University of Ioannina – sequence: 13 givenname: Georgios surname: Theophilou fullname: Theophilou, Georgios organization: St James Hospital – sequence: 14 givenname: Pierre L. surname: Martin-Hirsch fullname: Martin-Hirsch, Pierre L. organization: Centre for Biophotonics, LEC, Lancaster University, Department of Obstetrics and Gynaecology, Lancashire Teaching Hospitals NHS Trust Foundation – sequence: 15 givenname: Antonio surname: Cricenti fullname: Cricenti, Antonio organization: Istituto di Struttura della Materia, CNR – sequence: 16 givenname: Marco surname: Luce fullname: Luce, Marco organization: Istituto di Struttura della Materia, CNR – sequence: 17 givenname: Peter surname: Weightman fullname: Weightman, Peter organization: Department of Physics, University of Liverpool, Oliver Lodge Building – sequence: 18 givenname: Francis L. surname: Martin fullname: Martin, Francis L. organization: Centre for Biophotonics, LEC, Lancaster University, School of Pharmacy and Biomedical Sciences, University of Central Lancashire |
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| Cites_doi | 10.1063/1.4790436 10.1590/S0103-50532007000800021 10.1016/j.colsurfa.2007.04.173 10.1039/fd9949900181 10.1039/C3AY42224K 10.1016/j.nima.2012.02.049 10.1128/JVI.78.21.11451-11460.2004 10.1039/C5AN00939A 10.1371/journal.pone.0082416 10.1038/nature03680 10.1039/C4AY01736F 10.1371/journal.pone.0031592 10.1242/dmm.011338 10.1039/c3an36527a 10.1039/b109279k 10.1080/05704920701829043 10.1186/s12951-014-0061-5 10.1007/s00705-003-0111-z 10.1155/2005/798710 10.1016/S0168-1702(02)00188-0 10.1080/00401706.1969.10490666 10.1021/ac4025889 |
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| Title | Imaging cervical cytology with scanning near-field optical microscopy (SNOM) coupled with an IR-FEL |
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