Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

[Display omitted] Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety...

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Published in:Advanced drug delivery reviews Vol. 175; p. 113775
Main Authors: Nagelkerke, Anika, Ojansivu, Miina, van der Koog, Luke, Whittaker, Thomas E., Cunnane, Eoghan M., Silva, Andreia M., Dekker, Niek, Stevens, Molly M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.08.2021
Subjects:
Animals
Clinical trial
Drug Delivery Systems - methods
EV engineering
EV-functionalized biomaterials
Extracellular Vesicles - physiology
Humans
Mesenchymal stem cells
Regenerative medicine
Regenerative Medicine - methods
Therapeutic cargo delivery
Tissue Engineering - methods
Therapeutic cargo delivery
Clinical trial
Regenerative medicine
EV engineering
EV-functionalized biomaterials
Mesenchymal stem cells
ISSN:0169-409X, 1872-8294, 1872-8294
Online Access:Get full text
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Summary:[Display omitted] Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting as delivery vehicles for molecular messages. During the last decade, EVs have been assigned multiple functions that have established their potential as therapeutic mediators for a variety of diseases and conditions. In this review paper, we report on the potential of EVs in tissue repair and regeneration. The regenerative properties that have been associated with EVs are explored, detailing the molecular cargo they carry that is capable of mediating such effects, the signaling cascades triggered in target cells and the functional outcome achieved. EV interactions and biodistribution in vivo that influence their regenerative effects are also described, particularly upon administration in combination with biomaterials. Finally, we review the progress that has been made for the successful implementation of EV regenerative therapies in a clinical setting.
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2021.04.013