Comparing outpatient oral antibiotic use in Germany and the Netherlands from 2012 to 2016

Purpose Overuse of antibiotics is of concern, but may differ between European countries. This study compares outpatient use of oral antibiotics between Germany (DE) and the Netherlands (NL). Methods For DE, we used the DAPI database with information on dispensings at the expense of the Statutory Hea...

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Vydáno v:Pharmacoepidemiology and drug safety Ročník 27; číslo 12; s. 1344 - 1355
Hlavní autoři: Gradl, Gabriele, Teichert, Martina, Kieble, Marita, Werning, Johanna, Schulz, Martin
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.12.2018
John Wiley and Sons Inc
Témata:
Administration, Oral
Adolescent
Age
Age Factors
ambulatory care
Ambulatory Care - statistics & numerical data
Ambulatory Care - trends
Anti-Bacterial Agents - administration & dosage
Antibiotics
anti‐bacterial agents
Cephalosporins
Child
Child, Preschool
Children
Databases, Factual - statistics & numerical data
Drug Prescriptions - standards
Drug Prescriptions - statistics & numerical data
drug utilization
Drug Utilization - standards
Drug Utilization - statistics & numerical data
Drug Utilization - trends
Drug Utilization Review
Germany
Humans
Infant
Infant, Newborn
Longitudinal Studies
Netherlands
Original Report
Original Reports
Pharmacies - statistics & numerical data
pharmacoepidemiology
Practice Guidelines as Topic
Netherlands
Germany
Netherlands
ambulatory care
drug utilization
anti-bacterial agents
Germany
pharmacoepidemiology
ISSN:1053-8569, 1099-1557, 1099-1557
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Shrnutí:Purpose Overuse of antibiotics is of concern, but may differ between European countries. This study compares outpatient use of oral antibiotics between Germany (DE) and the Netherlands (NL). Methods For DE, we used the DAPI database with information on dispensings at the expense of the Statutory Health Insurance Funds from > 80% of community pharmacies. For NL, data were obtained from the Dutch Foundation for Pharmaceutical Statistics. Use of oral antibiotics was estimated as defined daily doses per 1000 inhabitants per day (DID), except for age comparisons as packages per 1000 inhabitants annually. National time trends were assessed with linear regression, stratified for the major antibiotic classes, and individual substances. Results From 2012 to 2016, outpatient antibiotic use was lower in NL than in DE (9.64 vs 14.14 DID in 2016) and non‐significantly decreased slightly over time in both countries. In DE, dispensings of oral antibiotics to children were higher compared with NL for the age groups 2 to 5 (2.0‐fold in 2016) and 6 to 14 years (2.7‐fold in 2016). Use of cephalosporins was very low in NL (0.02 DID in 2016), but the second most frequently dispensed class in DE (2.95 DID in 2016). Conclusion From 2012 to 2016, outpatient use of oral antibiotics was lower in NL than in DE. Differences were primarily observed in the age groups 2 to 5 and 6 to 14 years, although the recommendations of evidence‐based guidelines in both countries were in agreement.
Bibliografie:Statement about prior postings and presentations
Parts of the results have been presented at the 46th ESCP Symposium on Clinical Pharmacy (Heidelberg, Germany 9‐11 Oct 2017) as a poster.
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All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
ISSN:1053-8569
1099-1557
1099-1557
DOI:10.1002/pds.4643