Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight

The quick widespread of the coronavirus and speedy upsurge in the tally of cases demand the fast development of effective drugs. The uridine‐directed endoribonuclease activity of nonstructural protein 15 (Nsp15) of the coronavirus is responsible for the invasion of the host immune system. Therefore,...

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Vydané v:	Cell biochemistry and function Ročník 40; číslo 8; s. 926 - 934
Hlavní autori:	Singh, Rahul, Bhardwaj, Vijay K., Purohit, Rituraj
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Wiley Subscription Services, Inc 01.12.2022 John Wiley and Sons Inc
Predmet:	Antiviral Agents - pharmacology boiled‐egg Computer applications Coronaviruses COVID-19 Drug development Dynamic stability Endoribonucleases - chemistry Endoribonucleases - metabolism Humans Immune system Immunosuppressive agents Inhibitors Modulators Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Molecular interactions Nsp15 endoribonuclease Pharmacokinetics Pharmacology Proteins SARS-CoV-2 - metabolism SARS‐CoV‐2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Simulation Uridine Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism boiled-egg SARS-CoV-2 Nsp15 endoribonuclease molecular dynamics
ISSN:	0263-6484, 1099-0844, 1099-0844
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