Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity

•Engaging in physical activity can reduce depressive symptoms.•Exercise stimulates several neuroplastic processes implicated in depression.•It also reduces inflammation and increases resilience to oxidative and physiological stress.•Exercise promotes self-esteem, social support and self-efficacy.•Un...

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Vydané v:Neuroscience and biobehavioral reviews Ročník 107; s. 525 - 539
Hlavní autori: Kandola, Aaron, Ashdown-Franks, Garcia, Hendrikse, Joshua, Sabiston, Catherine M., Stubbs, Brendon
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Ltd 01.12.2019
Predmet:
Antidepressive Agents - therapeutic use
BDNF
Depression
Depression - drug therapy
Depression - psychology
Depressive Disorder - drug therapy
Depressive Disorder - psychology
Exercise
Exercise - psychology
Hippocampus
HPA
Humans
Inflammation
Mental health
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Neuroplasticity
Non-pharmacological
Oxidative stress
Self-efficacy
Self-esteem
Social Support
Stress
Neuroplasticity
Oxidative stress
BDNF
Mental health
Depression
Inflammation
Stress
Exercise
Self-efficacy
HPA
Self-esteem
Non-pharmacological
Hippocampus
Social support
ISSN:0149-7634, 1873-7528, 1873-7528
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Popis
Shrnutí:•Engaging in physical activity can reduce depressive symptoms.•Exercise stimulates several neuroplastic processes implicated in depression.•It also reduces inflammation and increases resilience to oxidative and physiological stress.•Exercise promotes self-esteem, social support and self-efficacy.•Understanding these mechanisms can improve the design of exercise interventions and maximise treatment response. Physical activity can treat and prevent depressive symptoms, but its antidepressant mechanisms are yet to be established. In this review, we comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise. Exercise, a subset of physical activity, influences a range of biological and psychosocial processes also implicated in the pathophysiology of depression. We focus on the capacity for exercise to elicit changes in neuroplasticity, inflammation, oxidative stress, the endocrine system, self-esteem, social support and self-efficacy. We also discuss how a better understanding of these mechanisms can inform the way we design and implement exercise-based interventions to maximise their antidepressant effects on an individual basis. We conclude by presenting a conceptual framework of the key biological and psychosocial mechanisms underlying the relationship between physical activity and depressive symptoms, and the moderators and confounders that may influence it.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0149-7634
1873-7528
1873-7528
DOI:10.1016/j.neubiorev.2019.09.040