Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue

To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI). Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point num...

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Veröffentlicht in:World journal of gastroenterology : WJG Jg. 23; H. 6; S. 1018
Hauptverfasser: van Erp, Sanne, Ercan, Ece, Breedveld, Perla, Brakenhoff, Lianne, Ghariq, Eidrees, Schmid, Sophie, van Osch, Matthias, van Buchem, Mark, Emmer, Bart, van der Grond, Jeroen, Wolterbeek, Ron, Hommes, Daniel, Fidder, Herma, van der Wee, Nic, Huizinga, Tom, van der Heijde, Désirée, Middelkoop, Huub, Ronen, Itamar, van der Meulen-de Jong, Andrea
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 14.02.2017
Schlagworte:
Adult
Affect
Anxiety - physiopathology
Brain - diagnostic imaging
Brain - physiopathology
Case-Control Studies
Cerebrovascular Circulation
Cognition
Creatine - blood
Crohn Disease - blood
Crohn Disease - complications
Crohn Disease - psychology
Depression - physiopathology
Executive Function
Fatigue - blood
Fatigue - etiology
Fatigue - physiopathology
Female
Glutamic Acid - blood
Glutamine - blood
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Quality of Life
Young Adult
Fatigue
Cognition
Magnetic resonance imaging
Systemic inflammation
Crohn’s disease
ISSN:2219-2840, 2219-2840
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Zusammenfassung:To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI). Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups. Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations ( = 0.02) and ratios to total creatine ( = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow ( = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms ( < 0.001). Cognitive functioning scores related to memory ( = 0.007) and executive functioning ( = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T -weighted analysis. In addition, no correlation was found between mental status and MRI findings. This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2219-2840
2219-2840
DOI:10.3748/wjg.v23.i6.1018