Overgrowth of a Mouse Model of the Simpson–Golabi–Behmel Syndrome Is Independent of IGF Signaling

The type 1 Simpson–Golabi–Behmel overgrowth syndrome (SGBS1) is caused by loss-of-function mutations of the X-linked GPC3 gene encoding glypican-3, a cell-surface heparan sulfate proteoglycan that apparently plays a negative role in growth control by an unknown mechanism. Mice carrying a Gpc3 gene k...

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Bibliographic Details
Published in:	Developmental biology Vol. 243; no. 1; pp. 185 - 206
Main Authors:	Chiao, Eric, Fisher, Peter, Crisponi, Laura, Deiana, Manila, Dragatsis, Ioannis, Schlessinger, David, Pilia, Giuseppe, Efstratiadis, Argiris
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.03.2002
Subjects:	Abnormalities, Multiple - genetics Animals Disease Models, Animal Female Gene Deletion Gene Expression Regulation glypican Glypicans growth Heparan Sulfate Proteoglycans - genetics insulin-like growth factor Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor II - genetics Male Mice Mice, Knockout proteoglycans Receptor, IGF Type 1 - genetics Signal Transduction - genetics Simpson–Golabi–Behmel syndrome proteoglycans growth insulin-like growth factor Simpson–Golabi–Behmel syndrome glypican
ISSN:	0012-1606, 1095-564X
Online Access:	Get full text
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