Hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots

To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JM...

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Bibliographic Details
Published in:Nanomedicine (London, England) Vol. 14; no. 4; pp. 431 - 446
Main Authors: Cheng, Jinjun, Zhang, Meiling, Sun, Ziwei, Lu, Fang, Xiong, Wei, Luo, Juan, Kong, Hui, Wang, Qingguo, Qu, Huihua, Zhao, Yan
Format: Journal Article
Language:English
Published: England Future Medicine Ltd 01.02.2019
Subjects:
Biological activity
Carbon
carbon dots
Fourier transforms
Hemorrhage
hemostatic bioactivity
Junci Medulla Carbonisata
Laboratory animals
liver protection
Nanocrystals
Quantum dots
Snakes
Traditional Chinese medicine
Trauma
Venom
Beijing China
United States > US
China
Japan
carbon dots
liver protection
Junci Medulla Carbonisata
hemostatic bioactivity
ISSN:1743-5889, 1748-6963, 1748-6963
Online Access:Get full text
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Summary:To explore the hemostatic and hepatoprotective bioactivity of Junci Medulla Carbonisata-derived Carbon Dots (JMC-CDs). The JMC-CDs were characterized using transmission electron microscopy, HPLC, Fourier transform IR, UV, fluorescence and x-ray photoelectron spectroscopy. The hemostatic effect of JMC-CDs was evaluated and confirmed by trauma hemorrhagic animal models and internal hemorrhage animal model induced by venom. The JMC-CDs ranged in diameter from 1.0 to 8 nm and had a yield of 0.12%. Moreover, JMC-CDs not only possessed remarkable hemostatic efficacy but could also prevent hemorrhage-induced liver injury, as demonstrated by the reduced serum levels of biochemical indicators of liver damage such as aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin and direct bilirubin. The JMC-CDs may have great potentials in clinical practice.
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ISSN:1743-5889
1748-6963
1748-6963
DOI:10.2217/nnm-2018-0285