Associations of Metabolic Syndrome and Abdominal Obesity with Anion Gap Metabolic Acidosis among US Adults
Visual Abstract Key Points Waist circumference and metabolic syndrome features were associated with greater risk of anion gap metabolic acidosis and its components. Findings were preserved after excluding CKD (eGFR <90 ml/min per 1.73 m2 or urine albumin to creatinine ratio ≥30 mg/g). Clear assoc...
Gespeichert in:
| Veröffentlicht in: | Kidney360 Jg. 3; H. 11; S. 1842 - 1851 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
American Society of Nephrology
24.11.2022
|
| Schlagworte: | |
| ISSN: | 2641-7650, 2641-7650 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Visual Abstract
Key Points
Waist circumference and metabolic syndrome features were associated with greater risk of anion gap metabolic acidosis and its components.
Findings were preserved after excluding CKD (eGFR <90 ml/min per 1.73 m2 or urine albumin to creatinine ratio ≥30 mg/g).
Clear associations were evident for anion gap metabolic acidosis, but not for nonanion gap metabolic acidosis.
Background
Obesity is a recently identified risk factor for metabolic acidosis and anion gap elevations in the absence of CKD. Metabolic acidosis is a treatable condition with substantial adverse effects on human health. Additional investigations are needed to characterize at-risk populations and explore potential mechanisms. We hypothesized metabolic syndrome (MetS) and waist circumference (WC) would be closely associated with this pathology.
Methods
Adult participants from NHANES 1999-2018 meeting study criteria were compiled as main (n=31,163) and fasting (n=12,860) cohorts. Regression models adjusted for dietary acid, eGFR, and other factors examined associations of WC and MetS features with anion gap metabolic acidosis and its components (serum bicarbonate ≤23 mEq/L and anion gap >95th percentile).
Results
Greater WC and MetS features were associated with progressively lower bicarbonate, higher anion gap, and greater odds ratios (OR) of metabolic acidosis (MA) and anion gap metabolic acidosis (AGMA). Compared with the reference, participants with the highest WC had ORs for MA and AGMA of 2.26; 95% CI, 1.96 to 2.62 and 2.89; 95% CI, 1.97 to 4.21; those with three and four versus zero MetS features had ORs for AGMA of 2.52; 95% CI, 1.95 to 2.94 and 3.05; 95% CI, 2.16 to 3.82. Associations of body mass index with outcomes were attenuated or absent after adjustment for WC or MetS. Findings were preserved after excluding eGFR <90 ml/min per 1.73 m2 and albuminuria. A lower MA cutoff (<22 mEq/L) raised the estimate of association between MetS and MA (OR for three and four vs zero features: 3.56; 95% CI, 2.53 to 5.02 and 5.44; 95% CI, 3.66 to 8.08).
Conclusions
Metabolic diseases are characterized by metabolic acidosis and anion gap elevations. Metabolic dysfunction may predispose patients without CKD to systemic acidosis from endogenous sources. Comprehensive acid-base analyses may be informative in patients with metabolic diseases. |
|---|---|
| AbstractList | Waist circumference and metabolic syndrome features were associated with greater risk of anion gap metabolic acidosis and its components.Findings were preserved after excluding CKD (eGFR <90 ml/min per 1.73 m2 or urine albumin to creatinine ratio ≥30 mg/g).Clear associations were evident for anion gap metabolic acidosis, but not for nonanion gap metabolic acidosis. Obesity is a recently identified risk factor for metabolic acidosis and anion gap elevations in the absence of CKD. Metabolic acidosis is a treatable condition with substantial adverse effects on human health. Additional investigations are needed to characterize at-risk populations and explore potential mechanisms. We hypothesized metabolic syndrome (MetS) and waist circumference (WC) would be closely associated with this pathology.BackgroundObesity is a recently identified risk factor for metabolic acidosis and anion gap elevations in the absence of CKD. Metabolic acidosis is a treatable condition with substantial adverse effects on human health. Additional investigations are needed to characterize at-risk populations and explore potential mechanisms. We hypothesized metabolic syndrome (MetS) and waist circumference (WC) would be closely associated with this pathology.Adult participants from NHANES 1999-2018 meeting study criteria were compiled as main (n=31,163) and fasting (n=12,860) cohorts. Regression models adjusted for dietary acid, eGFR, and other factors examined associations of WC and MetS features with anion gap metabolic acidosis and its components (serum bicarbonate ≤23 mEq/L and anion gap >95th percentile).MethodsAdult participants from NHANES 1999-2018 meeting study criteria were compiled as main (n=31,163) and fasting (n=12,860) cohorts. Regression models adjusted for dietary acid, eGFR, and other factors examined associations of WC and MetS features with anion gap metabolic acidosis and its components (serum bicarbonate ≤23 mEq/L and anion gap >95th percentile).Greater WC and MetS features were associated with progressively lower bicarbonate, higher anion gap, and greater odds ratios (OR) of metabolic acidosis (MA) and anion gap metabolic acidosis (AGMA). Compared with the reference, participants with the highest WC had ORs for MA and AGMA of 2.26; 95% CI, 1.96 to 2.62 and 2.89; 95% CI, 1.97 to 4.21; those with three and four versus zero MetS features had ORs for AGMA of 2.52; 95% CI, 1.95 to 2.94 and 3.05; 95% CI, 2.16 to 3.82. Associations of body mass index with outcomes were attenuated or absent after adjustment for WC or MetS. Findings were preserved after excluding eGFR <90 ml/min per 1.73 m2 and albuminuria. A lower MA cutoff (<22 mEq/L) raised the estimate of association between MetS and MA (OR for three and four vs zero features: 3.56; 95% CI, 2.53 to 5.02 and 5.44; 95% CI, 3.66 to 8.08).ResultsGreater WC and MetS features were associated with progressively lower bicarbonate, higher anion gap, and greater odds ratios (OR) of metabolic acidosis (MA) and anion gap metabolic acidosis (AGMA). Compared with the reference, participants with the highest WC had ORs for MA and AGMA of 2.26; 95% CI, 1.96 to 2.62 and 2.89; 95% CI, 1.97 to 4.21; those with three and four versus zero MetS features had ORs for AGMA of 2.52; 95% CI, 1.95 to 2.94 and 3.05; 95% CI, 2.16 to 3.82. Associations of body mass index with outcomes were attenuated or absent after adjustment for WC or MetS. Findings were preserved after excluding eGFR <90 ml/min per 1.73 m2 and albuminuria. A lower MA cutoff (<22 mEq/L) raised the estimate of association between MetS and MA (OR for three and four vs zero features: 3.56; 95% CI, 2.53 to 5.02 and 5.44; 95% CI, 3.66 to 8.08).Metabolic diseases are characterized by metabolic acidosis and anion gap elevations. Metabolic dysfunction may predispose patients without CKD to systemic acidosis from endogenous sources. Comprehensive acid-base analyses may be informative in patients with metabolic diseases.ConclusionsMetabolic diseases are characterized by metabolic acidosis and anion gap elevations. Metabolic dysfunction may predispose patients without CKD to systemic acidosis from endogenous sources. Comprehensive acid-base analyses may be informative in patients with metabolic diseases. Obesity is a recently identified risk factor for metabolic acidosis and anion gap elevations in the absence of CKD. Metabolic acidosis is a treatable condition with substantial adverse effects on human health. Additional investigations are needed to characterize at-risk populations and explore potential mechanisms. We hypothesized metabolic syndrome (MetS) and waist circumference (WC) would be closely associated with this pathology. Adult participants from NHANES 1999-2018 meeting study criteria were compiled as main ( =31,163) and fasting ( =12,860) cohorts. Regression models adjusted for dietary acid, eGFR, and other factors examined associations of WC and MetS features with anion gap metabolic acidosis and its components (serum bicarbonate ≤23 mEq/L and anion gap >95th percentile). Greater WC and MetS features were associated with progressively lower bicarbonate, higher anion gap, and greater odds ratios (OR) of metabolic acidosis (MA) and anion gap metabolic acidosis (AGMA). Compared with the reference, participants with the highest WC had ORs for MA and AGMA of 2.26; 95% CI, 1.96 to 2.62 and 2.89; 95% CI, 1.97 to 4.21; those with three and four versus zero MetS features had ORs for AGMA of 2.52; 95% CI, 1.95 to 2.94 and 3.05; 95% CI, 2.16 to 3.82. Associations of body mass index with outcomes were attenuated or absent after adjustment for WC or MetS. Findings were preserved after excluding eGFR <90 ml/min per 1.73 m and albuminuria. A lower MA cutoff (<22 mEq/L) raised the estimate of association between MetS and MA (OR for three and four vs zero features: 3.56; 95% CI, 2.53 to 5.02 and 5.44; 95% CI, 3.66 to 8.08). Metabolic diseases are characterized by metabolic acidosis and anion gap elevations. Metabolic dysfunction may predispose patients without CKD to systemic acidosis from endogenous sources. Comprehensive acid-base analyses may be informative in patients with metabolic diseases. Visual Abstract Key Points Waist circumference and metabolic syndrome features were associated with greater risk of anion gap metabolic acidosis and its components. Findings were preserved after excluding CKD (eGFR <90 ml/min per 1.73 m2 or urine albumin to creatinine ratio ≥30 mg/g). Clear associations were evident for anion gap metabolic acidosis, but not for nonanion gap metabolic acidosis. Background Obesity is a recently identified risk factor for metabolic acidosis and anion gap elevations in the absence of CKD. Metabolic acidosis is a treatable condition with substantial adverse effects on human health. Additional investigations are needed to characterize at-risk populations and explore potential mechanisms. We hypothesized metabolic syndrome (MetS) and waist circumference (WC) would be closely associated with this pathology. Methods Adult participants from NHANES 1999-2018 meeting study criteria were compiled as main (n=31,163) and fasting (n=12,860) cohorts. Regression models adjusted for dietary acid, eGFR, and other factors examined associations of WC and MetS features with anion gap metabolic acidosis and its components (serum bicarbonate ≤23 mEq/L and anion gap >95th percentile). Results Greater WC and MetS features were associated with progressively lower bicarbonate, higher anion gap, and greater odds ratios (OR) of metabolic acidosis (MA) and anion gap metabolic acidosis (AGMA). Compared with the reference, participants with the highest WC had ORs for MA and AGMA of 2.26; 95% CI, 1.96 to 2.62 and 2.89; 95% CI, 1.97 to 4.21; those with three and four versus zero MetS features had ORs for AGMA of 2.52; 95% CI, 1.95 to 2.94 and 3.05; 95% CI, 2.16 to 3.82. Associations of body mass index with outcomes were attenuated or absent after adjustment for WC or MetS. Findings were preserved after excluding eGFR <90 ml/min per 1.73 m2 and albuminuria. A lower MA cutoff (<22 mEq/L) raised the estimate of association between MetS and MA (OR for three and four vs zero features: 3.56; 95% CI, 2.53 to 5.02 and 5.44; 95% CI, 3.66 to 8.08). Conclusions Metabolic diseases are characterized by metabolic acidosis and anion gap elevations. Metabolic dysfunction may predispose patients without CKD to systemic acidosis from endogenous sources. Comprehensive acid-base analyses may be informative in patients with metabolic diseases. |
| Author | Kane, Jamie Lambert, Douglas C. Abramowitz, Matthew K. Slaton, Anthony |
| Author_xml | – sequence: 1 givenname: Douglas C. orcidid: 0000-0003-3857-5005 surname: Lambert fullname: Lambert, Douglas C. organization: Department of Medicine, Section of Obesity Medicine, Northwell Health, New York – sequence: 2 givenname: Jamie orcidid: 0000-0002-3204-4425 surname: Kane fullname: Kane, Jamie organization: Department of Medicine, Section of Obesity Medicine, Northwell Health, New York – sequence: 3 givenname: Anthony orcidid: 0000-0002-3036-197X surname: Slaton fullname: Slaton, Anthony organization: Department of General Internal Medicine, Northwell Health, Great Neck, New York – sequence: 4 givenname: Matthew K. orcidid: 0000-0001-6984-9799 surname: Abramowitz fullname: Abramowitz, Matthew K. organization: Department of Medicine, Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, Bronx, New York |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36514392$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1vFCEYh4mpsR_27M1w9LIt38xcTCZVa2NND7VnwgDTpTKwAuNm__tOu7WuJnqChOf5vW_4HYK9mKID4A1GJ5QhIU-_XHw4QQgRhggi5AU4IILhhRQc7e3c98FxKXcPXEtIQ8UrsE8Fx4y25ADcdaUk43X1KRaYBvjVVd2n4A283kSb0-igjhZ2vU2jjzrAq94VXzdw7esSdnH24Lle7Xid8TYVX6AeU7yFN9ews1Oo5TV4OehQ3PHTeQRuPn38dvZ5cXl1fnHWXS4Mo5IsBGMcE0sJsqRvmCZGOItN01iMeoE01YPFjWFEMmxkj7BsB6ox50NLtMY9PQLvt7mrqR-dNS7WrINaZT_qvFFJe_XnS_RLdZt-qlZiKZicA949BeT0Y3KlqtEX40LQ0aWpKCI544hw-YC-3Z31POTXB8_A6RYwOZWS3fCMYKQeW1Rzi-p3i7PB_zKMr4_9zMv68B-Pbr11CtXl8j1Ma5fV0ulQl_-07gHoJa__ |
| CitedBy_id | crossref_primary_10_1038_s41598_024_71202_y crossref_primary_10_34067_KID_0005142022 crossref_primary_10_1002_oby_24086 crossref_primary_10_1007_s00424_024_02910_7 crossref_primary_10_1053_j_ackd_2022_07_008 crossref_primary_10_3390_cimb47040218 |
| Cites_doi | 10.34067/KID.0000532019 10.7326/0003-4819-150-9-200905050-00006 10.1056/NEJM199406233302502 10.1001/jama.285.19.2486 10.1007/BF00280883 10.1016/j.xkme.2021.02.006 10.1210/jcem.82.1.3663 10.2215/CJN.05480614 10.1210/jc.2015-2555 10.1111/j.1464-5491.2008.02471.x 10.1378/chest.15-1703 10.1016/j.mce.2015.02.018 10.2215/CJN.10420818 10.1038/ki.1986.62 10.34067/KID.0003562021 10.1038/ki.2010.388 10.2215/CJN.03600413 10.2215/CJN.08331109 10.1152/ajprenal.00587.2010 10.1016/j.mito.2014.05.007 10.1016/j.metabol.2010.03.006 10.1038/ki.2012.196 10.1053/j.ajkd.2009.02.014 10.1152/ajprenal.00496.2018 10.2337/diabetes.51.10.2944 10.1111/obr.12958 10.1093/ajh/hpu117 10.1053/j.ajkd.2015.08.028 10.3390/antiox10010002 10.3109/10641963.2016.1174247 10.1096/fasebj.6.7.1563593 10.1097/00003246-199811000-00019 10.1172/JCI111614 10.1016/j.jhep.2020.11.028 10.1681/ASN.2008020159 10.1152/ajpregu.00114.2004 10.1007/s11695-010-0306-9 10.1111/nep.12315 10.1093/ajcn/68.3.576 10.1016/j.kint.2016.10.023 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 by the American Society of Nephrology Copyright © 2022 by the American Society of Nephrology. Copyright © 2022 by the American Society of Nephrology 2022 |
| Copyright_xml | – notice: Copyright © 2022 by the American Society of Nephrology – notice: Copyright © 2022 by the American Society of Nephrology. – notice: Copyright © 2022 by the American Society of Nephrology 2022 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.34067/KID.0002402022 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2641-7650 |
| EndPage | 1851 |
| ExternalDocumentID | PMC9717647 36514392 10_34067_KID_0002402022 K3602022000240 |
| Genre | research-article Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIDDK NIH HHS grantid: P30 DK020541 |
| GroupedDBID | 0R~ 53G AAAAV AAHPQ AAIQE AASCR AAUIN ABASU ABDIG ABVCZ ABXYN ABZZY ACILI ACLDA ACXJB ACZKN ADGGA ADHPY ADPDF ADSXY AFBFQ AFDTB AFEXH AFNMH AHOMT AHQNM AHQVU AINUH AJCLO AJNWD AJZMW AKCTQ ALKUP ALMA_UNASSIGNED_HOLDINGS AMJPA AMKUR AMNEI AOHHW AOQMC DIWNM EBS EEVPB ERAAH FCALG GNXGY GQDEL GROUPED_DOAJ HLJTE IKREB M~E OPUJH OVD OVDNE RPM TEORI TSPGW AAYXX ACBKD ADKSD CITATION ACIJW CGR CUY CVF ECM EIF NPM RHF 7X8 5PM |
| ID | FETCH-LOGICAL-c4372-644512d320d2b84a2c6ed1c88d10b60a3afd18c42741c7b0179f3a155f92aa1b3 |
| ISICitedReferencesCount | 8 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000889087100007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2641-7650 |
| IngestDate | Tue Nov 04 02:06:54 EST 2025 Mon Sep 08 17:00:04 EDT 2025 Wed Feb 19 02:25:22 EST 2025 Sat Nov 29 07:39:24 EST 2025 Tue Nov 18 21:47:33 EST 2025 Mon Aug 25 20:30:52 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | metabolic syndrome acid-base equilibrium metabolic acidosis anion gap acid/base and electrolyte disorders abdominal obesity waist circumference obesity |
| Language | English |
| License | Copyright © 2022 by the American Society of Nephrology. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4372-644512d320d2b84a2c6ed1c88d10b60a3afd18c42741c7b0179f3a155f92aa1b3 |
| Notes | Correspondence: D. Lambert, MD, MPH, Irving Goldman Family Care Center, 865 Northern Boulevard, Suite 102, Great Neck, NY 11021. Email: dlambert1@northwell.edu ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-3857-5005 0000-0001-6984-9799 0000-0002-3204-4425 0000-0002-3036-197X 0000-0002-3036-197 |
| OpenAccessLink | http://dx.doi.org/10.34067/KID.0002402022 |
| PMID | 36514392 |
| PQID | 2754502577 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9717647 proquest_miscellaneous_2754502577 pubmed_primary_36514392 crossref_primary_10_34067_KID_0002402022 crossref_citationtrail_10_34067_KID_0002402022 wolterskluwer_health_10_34067_KID_0002402022 |
| PublicationCentury | 2000 |
| PublicationDate | 20221124 |
| PublicationDateYYYYMMDD | 2022-11-24 |
| PublicationDate_xml | – month: 11 year: 2022 text: 20221124 day: 24 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Kidney360 |
| PublicationTitleAbbrev | Kidney360 |
| PublicationTitleAlternate | Kidney360 |
| PublicationYear | 2022 |
| Publisher | American Society of Nephrology |
| Publisher_xml | – name: American Society of Nephrology |
| References | Adeva-Andany, López-Ojén, Funcasta-Calderón, Ameneiros-Rodríguez, Donapetry-García, Vila-Altesor, Rodríguez-Seijas (B36) 2014; 17 Lian, Zhuo, Tian, Liu (B26) 2016; 38 Robergs, Ghiasvand, Parker (B28) 2004; 287 Frassetto, Morris, Sebastian (B10) 1997; 82 Spahr, Negro, Leandro, Marinescu, Goodman, Rubbia-Brandt, Jordan, Hadengue (B34) 2003; 9 Aryal, Roy, Chamcheu, Jackson (B46) 2020; 10 Maalouf, Cameron, Moe, Sakhaee (B42) 2010; 5 DiGirolamo, Newby, Lovejoy (B31) 1992; 6 Frassetto, Todd, Morris, Sebastian (B16) 1998; 68 Newby, Sykes, DiGirolamo (B39) 1988; 255 Centers for Disease Control and Prevention (CDC) . National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/nchs/nhanes/index.htm. Accessed August 1, 2020. Wesson, Pruszynski, Cai, Simoni (B40) 2017; 91 Raphael, Wei, Baird, Greene, Beddhu (B8) 2011; 79 Lambert, Abramowitz (B5) 2021; 2 Kalhan, Guo, Edmison, Dasarathy, McCullough, Hanson, Milburn (B30) 2011; 60 Madias (B35) 1986; 29 Cogan (B44) 1984; 74 Moranne, Froissart, Rossert, Gauci, Boffa, Haymann, M'rad, Jacquot, Houillier, Stengel, Fouqueray (B24) 2009; 20 Gardner, Tuttle, Raphael (B22) 2020; 1 Kelley, He, Menshikova, Ritov (B33) 2002; 51 Wang, Chen, Yao, Zheng, He, Xia, Li, Shao, Zhang, Huang, Qin, Xu, Zhang, Pan, Li, Huang (B38) 2021; 74 Suetrong, Walley (B29) 2016; 149 Matthews, Hosker, Rudenski, Naylor, Treacher, Turner (B17) 1985; 28 Chen, Varasteh, Reaven (B25) 1993; 19 Kraut, Madias (B1) 2016; 67 Yin, Subramanian, Willinger, Chen, Juhasz, Courchesne, Chen, Li, Hwang, Fox, O'Donnell, Muntendam, Fuster, Bobeldijk-Pastorova, Sookoian, Pirola, Gordon, Adourian, Larson, Levy (B27) 2016; 101 Bobulescu, Park, Xu, Blanco, Poindexter, Adams-Huet, Davidson, Sakhaee, Maalouf, Moe (B41) 2019; 14 Abramowitz, Hostetter, Melamed (B3) 2012; 82 Heinonen, Jokinen, Rissanen, Pietiläinen (B32) 2020; 21 (B18) 2001; 285 Asrih, Jornayvaz (B37) 2015; 418 Amodu, Abramowitz (B14) 2013; 8 Juraschek, Bower, Selvin, Subash Shantha, Hoogeveen, Ballantyne, Young (B45) 2015; 28 Wesson, Simoni, Broglio, Sheather (B2) 2011; 300 Lambert, Abramowitz (B4) 2021; 3 Sebastian, Harris, Ottaway, Todd, Morris (B9) 1994; 330 Farwell, Taylor (B13) 2008; 25 Levey, Stevens, Schmid, Zhang, Castro, Feldman, Kusek, Eggers, Van Lente, Greene, Coresh (B15) 2009; 150 Shah, Abramowitz, Hostetter, Melamed (B7) 2009; 54 Yenchek, Ix, Rifkin, Shlipak, Sarnak, Garcia, Patel, Satterfield, Harris, Newman, Fried, Health (B11) 2014; 9 Figge, Jabor, Kazda, Fencl (B19) 1998; 26 Gabrielsen, Lund, Kongerud, Viken, Røislien, Hjelmesaeth (B43) 2011; 21 DeFronzo, Beckles (B6) 1979; 236 Raphael, Zhang, Ying, Greene (B12) 2014; 19 Banerjee, Crews, Wesson, McCulloch, Johansen, Saydah, Rios Burrows, Saran, Gillespie, Bragg-Gresham, Powe (B20) 2019; 316 Mokhlesi (B23) 2010; 55 Raphael (B8-20250825) 2011; 79 Bobulescu (B41-20250825) 2019; 14 Yin (B27-20250825) 2016; 101 Wesson (B40-20250825) 2017; 91 Lambert (B4-20250825) 2021; 3 Kraut (B1-20250825) 2016; 67 Raphael (B12-20250825) 2014; 19 Moranne (B24-20250825) 2009; 20 Amodu (B14-20250825) 2013; 8 Suetrong (B29-20250825) 2016; 149 Spahr (B34-20250825) 2003; 9 Abramowitz (B3-20250825) 2012; 82 Figge (B19-20250825) 1998; 26 Banerjee (B20-20250825) 2019; 316 Madias (B35-20250825) 1986; 29 Newby (B39-20250825) 1988; 255 Lambert (B5-20250825) 2021; 2 (B18-20250825) 2001; 285 Gabrielsen (B43-20250825) 2011; 21 Lian (B26-20250825) 2016; 38 DiGirolamo (B31-20250825) 1992; 6 Farwell (B13-20250825) 2008; 25 Chen (B25-20250825) 1993; 19 Asrih (B37-20250825) 2015; 418 DeFronzo (B6-20250825) 1979; 236 Maalouf (B42-20250825) 2010; 5 Frassetto (B16-20250825) 1998; 68 Kalhan (B30-20250825) 2011; 60 Wang (B38-20250825) 2021; 74 Kelley (B33-20250825) 2002; 51 Shah (B7-20250825) 2009; 54 Yenchek (B11-20250825) 2014; 9 Juraschek (B45-20250825) 2015; 28 Wesson (B2-20250825) 2011; 300 Robergs (B28-20250825) 2004; 287 Gardner (B22-20250825) 2020; 1 Adeva-Andany (B36-20250825) 2014; 17 Heinonen (B32-20250825) 2020; 21 Matthews (B17-20250825) 1985; 28 Mokhlesi (B23-20250825) 2010; 55 Cogan (B44-20250825) 1984; 74 Levey (B15-20250825) 2009; 150 Aryal (B46-20250825) 2020; 10 Frassetto (B10-20250825) 1997; 82 Sebastian (B9-20250825) 1994; 330 36514414 - Kidney360. 2022 Nov 24;3(11):1819-1822 |
| References_xml | – volume: 51 start-page: 2944 year: 2002 end-page: 2950 ident: B33 article-title: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes publication-title: Diabetes – reference: Centers for Disease Control and Prevention (CDC) . National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/nchs/nhanes/index.htm. Accessed August 1, 2020. – volume: 28 start-page: 216 year: 2015 end-page: 224 ident: B45 article-title: Plasma lactate and incident hypertension in the atherosclerosis risk in communities study publication-title: Am J Hypertens – volume: 20 start-page: 164 year: 2009 end-page: 171 ident: B24 article-title: Timing of onset of CKD-related metabolic complications publication-title: J Am Soc Nephrol – volume: 6 start-page: 2405 year: 1992 end-page: 2412 ident: B31 article-title: Lactate production in adipose tissue: A regulated function with extra-adipose implications publication-title: FASEB J – volume: 38 start-page: 541 year: 2016 end-page: 544 ident: B26 article-title: Increased plasma lactate level is associated with subclinical cardiovascular damage in patient with non-dipping hypertension publication-title: Clin Exp Hypertens – volume: 67 start-page: 307 year: 2016 end-page: 317 ident: B1 article-title: Metabolic acidosis of CKD: An update publication-title: Am J Kidney Dis – volume: 1 start-page: 330 year: 2020 end-page: 336 ident: B22 article-title: Influence of medications containing acid salts on serum bicarbonate in CKD publication-title: Kidney360 – volume: 287 start-page: R502 year: 2004 end-page: R516 ident: B28 article-title: Biochemistry of exercise-induced metabolic acidosis publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 91 start-page: 914 year: 2017 end-page: 927 ident: B40 article-title: Acid retention with reduced glomerular filtration rate increases urine biomarkers of kidney and bone injury publication-title: Kidney Int – volume: 9 start-page: 2111 year: 2014 end-page: 2116 ident: B11 article-title: Association of serum bicarbonate with incident functional limitation in older adults publication-title: Clin J Am Soc Nephrol – volume: 55 start-page: 1347 year: 2010 end-page: 1362, discussion 1363-1365 ident: B23 article-title: Obesity hypoventilation syndrome: A state-of-the-art review publication-title: Respir Care – volume: 316 start-page: F1244 year: 2019 end-page: F1253 ident: B20 article-title: Elevated serum anion gap in adults with moderate chronic kidney disease increases risk for progression to end-stage renal disease publication-title: Am J Physiol Renal Physiol – volume: 17 start-page: 76 year: 2014 end-page: 100 ident: B36 article-title: Comprehensive review on lactate metabolism in human health publication-title: Mitochondrion – volume: 8 start-page: 2034 year: 2013 end-page: 2042 ident: B14 article-title: Dietary acid, age, and serum bicarbonate levels among adults in the United States publication-title: Clin J Am Soc Nephrol – volume: 74 start-page: 1942 year: 1984 end-page: 1947 ident: B44 article-title: Chronic hypercapnia stimulates proximal bicarbonate reabsorption in the rat publication-title: J Clin Invest – volume: 68 start-page: 576 year: 1998 end-page: 583 ident: B16 article-title: Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents publication-title: Am J Clin Nutr – volume: 74 start-page: 1038 year: 2021 end-page: 1052 ident: B38 article-title: Acetylation of lactate dehydrogenase B drives NAFLD progression by impairing lactate clearance publication-title: J Hepatol – volume: 82 start-page: 701 year: 2012 end-page: 709 ident: B3 article-title: The serum anion gap is altered in early kidney disease and associates with mortality publication-title: Kidney Int – volume: 2 start-page: 1706 year: 2021 end-page: 1715 ident: B5 article-title: Obesity, anion accumulation, and anion gap metabolic acidosis: A cohort study publication-title: Kidney360 – volume: 82 start-page: 254 year: 1997 end-page: 259 ident: B10 article-title: Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women publication-title: J Clin Endocrinol Metab – volume: 14 start-page: 411 year: 2019 end-page: 420 ident: B41 article-title: Net acid excretion and urinary organic anions in idiopathic uric acid nephrolithiasis publication-title: Clin J Am Soc Nephrol – volume: 60 start-page: 404 year: 2011 end-page: 413 ident: B30 article-title: Plasma metabolomic profile in nonalcoholic fatty liver disease publication-title: Metabolism – volume: 29 start-page: 752 year: 1986 end-page: 774 ident: B35 article-title: Lactic acidosis publication-title: Kidney Int – volume: 25 start-page: 798 year: 2008 end-page: 804 ident: B13 article-title: Serum bicarbonate, anion gap and insulin resistance in the National Health and Nutrition Examination Survey publication-title: Diabet Med – volume: 19 start-page: 348 year: 1993 end-page: 354 ident: B25 article-title: Plasma lactate concentration in obesity and type 2 diabetes publication-title: Diabete Metab – volume: 149 start-page: 252 year: 2016 end-page: 261 ident: B29 article-title: Lactic acidosis in sepsis: It's not all anaerobic: Implications for diagnosis and management publication-title: Chest – volume: 10 start-page: 2 year: 2020 ident: B46 article-title: Chronic metabolic acidosis elicits hypertension via upregulation of intrarenal angiotensin II and induction of oxidative stress publication-title: Antioxidants – volume: 300 start-page: F830 year: 2011 end-page: F837 ident: B2 article-title: Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone publication-title: Am J Physiol Renal Physiol – volume: 150 start-page: 604 year: 2009 end-page: 612 ident: B15 article-title: A new equation to estimate glomerular filtration rate publication-title: Ann Intern Med – volume: 21 start-page: e12958 year: 2020 ident: B32 article-title: White adipose tissue mitochondrial metabolism in health and in obesity publication-title: Obes Rev – volume: 9 start-page: CR6 year: 2003 end-page: CR11 ident: B34 article-title: Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis publication-title: Med Sci Monit – volume: 79 start-page: 356 year: 2011 end-page: 362 ident: B8 article-title: Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans publication-title: Kidney Int – volume: 5 start-page: 1277 year: 2010 end-page: 1281 ident: B42 article-title: Metabolic basis for low urine pH in type 2 diabetes publication-title: Clin J Am Soc Nephrol – volume: 101 start-page: 1779 year: 2016 end-page: 1789 ident: B27 article-title: Metabolite signatures of metabolic risk factors and their longitudinal changes publication-title: J Clin Endocrinol Metab – volume: 26 start-page: 1807 year: 1998 end-page: 1810 ident: B19 article-title: Anion gap and hypoalbuminemia publication-title: Crit Care Med – volume: 3 start-page: 498 year: 2021 end-page: 506.e1 ident: B4 article-title: Obesity and the risk of low bicarbonate: A cohort study publication-title: Kidney Med – volume: 236 start-page: E328 year: 1979 end-page: E334 ident: B6 article-title: Glucose intolerance following chronic metabolic acidosis in man publication-title: Am J Physiol – volume: 54 start-page: 270 year: 2009 end-page: 277 ident: B7 article-title: Serum bicarbonate levels and the progression of kidney disease: A cohort study publication-title: Am J Kidney Dis – volume: 28 start-page: 412 year: 1985 end-page: 419 ident: B17 article-title: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia – volume: 285 start-page: 2486 year: 2001 end-page: 2497 ident: B18 article-title: Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) publication-title: JAMA – volume: 418 start-page: 55 year: 2015 end-page: 65 ident: B37 article-title: Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link? publication-title: Mol Cell Endocrinol – volume: 330 start-page: 1776 year: 1994 end-page: 1781 ident: B9 article-title: Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate publication-title: N Engl J Med – volume: 255 start-page: E716 year: 1988 end-page: E722 ident: B39 article-title: Regional differences in adipocyte lactate production from glucose publication-title: Am J Physiol – volume: 21 start-page: 485 year: 2011 end-page: 491 ident: B43 article-title: The relationship between anthropometric measures, blood gases, and lung function in morbidly obese White subjects publication-title: Obes Surg – volume: 19 start-page: 648 year: 2014 end-page: 654 ident: B12 article-title: Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease publication-title: Nephrology (Carlton) – volume: 1 start-page: 330 year: 2020 ident: B22-20250825 article-title: Influence of medications containing acid salts on serum bicarbonate in CKD publication-title: Kidney360 doi: 10.34067/KID.0000532019 – volume: 150 start-page: 604 year: 2009 ident: B15-20250825 article-title: A new equation to estimate glomerular filtration rate publication-title: Ann Intern Med doi: 10.7326/0003-4819-150-9-200905050-00006 – volume: 330 start-page: 1776 year: 1994 ident: B9-20250825 article-title: Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate publication-title: N Engl J Med doi: 10.1056/NEJM199406233302502 – volume: 285 start-page: 2486 year: 2001 ident: B18-20250825 article-title: Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) publication-title: JAMA doi: 10.1001/jama.285.19.2486 – volume: 28 start-page: 412 year: 1985 ident: B17-20250825 article-title: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 3 start-page: 498 year: 2021 ident: B4-20250825 article-title: Obesity and the risk of low bicarbonate: A cohort study publication-title: Kidney Med doi: 10.1016/j.xkme.2021.02.006 – volume: 82 start-page: 254 year: 1997 ident: B10-20250825 article-title: Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.82.1.3663 – volume: 9 start-page: 2111 year: 2014 ident: B11-20250825 article-title: Association of serum bicarbonate with incident functional limitation in older adults publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.05480614 – volume: 101 start-page: 1779 year: 2016 ident: B27-20250825 article-title: Metabolite signatures of metabolic risk factors and their longitudinal changes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2015-2555 – volume: 25 start-page: 798 year: 2008 ident: B13-20250825 article-title: Serum bicarbonate, anion gap and insulin resistance in the National Health and Nutrition Examination Survey publication-title: Diabet Med doi: 10.1111/j.1464-5491.2008.02471.x – volume: 149 start-page: 252 year: 2016 ident: B29-20250825 article-title: Lactic acidosis in sepsis: It’s not all anaerobic: Implications for diagnosis and management publication-title: Chest doi: 10.1378/chest.15-1703 – volume: 418 start-page: 55 year: 2015 ident: B37-20250825 article-title: Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link? publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2015.02.018 – volume: 14 start-page: 411 year: 2019 ident: B41-20250825 article-title: Net acid excretion and urinary organic anions in idiopathic uric acid nephrolithiasis publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.10420818 – volume: 29 start-page: 752 year: 1986 ident: B35-20250825 article-title: Lactic acidosis publication-title: Kidney Int doi: 10.1038/ki.1986.62 – volume: 9 start-page: CR6 year: 2003 ident: B34-20250825 article-title: Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis publication-title: Med Sci Monit – volume: 2 start-page: 1706 year: 2021 ident: B5-20250825 article-title: Obesity, anion accumulation, and anion gap metabolic acidosis: A cohort study publication-title: Kidney360 doi: 10.34067/KID.0003562021 – volume: 55 start-page: 1347 year: 2010 ident: B23-20250825 article-title: Obesity hypoventilation syndrome: A state-of-the-art review publication-title: Respir Care – volume: 79 start-page: 356 year: 2011 ident: B8-20250825 article-title: Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans publication-title: Kidney Int doi: 10.1038/ki.2010.388 – volume: 8 start-page: 2034 year: 2013 ident: B14-20250825 article-title: Dietary acid, age, and serum bicarbonate levels among adults in the United States publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.03600413 – volume: 5 start-page: 1277 year: 2010 ident: B42-20250825 article-title: Metabolic basis for low urine pH in type 2 diabetes publication-title: Clin J Am Soc Nephrol doi: 10.2215/CJN.08331109 – volume: 300 start-page: F830 year: 2011 ident: B2-20250825 article-title: Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00587.2010 – volume: 17 start-page: 76 year: 2014 ident: B36-20250825 article-title: Comprehensive review on lactate metabolism in human health publication-title: Mitochondrion doi: 10.1016/j.mito.2014.05.007 – volume: 19 start-page: 348 year: 1993 ident: B25-20250825 article-title: Plasma lactate concentration in obesity and type 2 diabetes publication-title: Diabete Metab – volume: 60 start-page: 404 year: 2011 ident: B30-20250825 article-title: Plasma metabolomic profile in nonalcoholic fatty liver disease publication-title: Metabolism doi: 10.1016/j.metabol.2010.03.006 – volume: 82 start-page: 701 year: 2012 ident: B3-20250825 article-title: The serum anion gap is altered in early kidney disease and associates with mortality publication-title: Kidney Int doi: 10.1038/ki.2012.196 – volume: 54 start-page: 270 year: 2009 ident: B7-20250825 article-title: Serum bicarbonate levels and the progression of kidney disease: A cohort study publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2009.02.014 – volume: 316 start-page: F1244 year: 2019 ident: B20-20250825 article-title: Elevated serum anion gap in adults with moderate chronic kidney disease increases risk for progression to end-stage renal disease publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00496.2018 – volume: 255 start-page: E716 year: 1988 ident: B39-20250825 article-title: Regional differences in adipocyte lactate production from glucose publication-title: Am J Physiol – volume: 51 start-page: 2944 year: 2002 ident: B33-20250825 article-title: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes publication-title: Diabetes doi: 10.2337/diabetes.51.10.2944 – volume: 21 start-page: e12958 year: 2020 ident: B32-20250825 article-title: White adipose tissue mitochondrial metabolism in health and in obesity publication-title: Obes Rev doi: 10.1111/obr.12958 – volume: 28 start-page: 216 year: 2015 ident: B45-20250825 article-title: Plasma lactate and incident hypertension in the atherosclerosis risk in communities study publication-title: Am J Hypertens doi: 10.1093/ajh/hpu117 – volume: 67 start-page: 307 year: 2016 ident: B1-20250825 article-title: Metabolic acidosis of CKD: An update publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2015.08.028 – volume: 10 start-page: 2 year: 2020 ident: B46-20250825 article-title: Chronic metabolic acidosis elicits hypertension via upregulation of intrarenal angiotensin II and induction of oxidative stress publication-title: Antioxidants doi: 10.3390/antiox10010002 – volume: 38 start-page: 541 year: 2016 ident: B26-20250825 article-title: Increased plasma lactate level is associated with subclinical cardiovascular damage in patient with non-dipping hypertension publication-title: Clin Exp Hypertens doi: 10.3109/10641963.2016.1174247 – volume: 6 start-page: 2405 year: 1992 ident: B31-20250825 article-title: Lactate production in adipose tissue: A regulated function with extra-adipose implications publication-title: FASEB J doi: 10.1096/fasebj.6.7.1563593 – volume: 26 start-page: 1807 year: 1998 ident: B19-20250825 article-title: Anion gap and hypoalbuminemia publication-title: Crit Care Med doi: 10.1097/00003246-199811000-00019 – volume: 236 start-page: E328 year: 1979 ident: B6-20250825 article-title: Glucose intolerance following chronic metabolic acidosis in man publication-title: Am J Physiol – volume: 74 start-page: 1942 year: 1984 ident: B44-20250825 article-title: Chronic hypercapnia stimulates proximal bicarbonate reabsorption in the rat publication-title: J Clin Invest doi: 10.1172/JCI111614 – volume: 74 start-page: 1038 year: 2021 ident: B38-20250825 article-title: Acetylation of lactate dehydrogenase B drives NAFLD progression by impairing lactate clearance publication-title: J Hepatol doi: 10.1016/j.jhep.2020.11.028 – volume: 20 start-page: 164 year: 2009 ident: B24-20250825 article-title: Timing of onset of CKD-related metabolic complications publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2008020159 – volume: 287 start-page: R502 year: 2004 ident: B28-20250825 article-title: Biochemistry of exercise-induced metabolic acidosis publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00114.2004 – volume: 21 start-page: 485 year: 2011 ident: B43-20250825 article-title: The relationship between anthropometric measures, blood gases, and lung function in morbidly obese White subjects publication-title: Obes Surg doi: 10.1007/s11695-010-0306-9 – volume: 19 start-page: 648 year: 2014 ident: B12-20250825 article-title: Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease publication-title: Nephrology (Carlton) doi: 10.1111/nep.12315 – volume: 68 start-page: 576 year: 1998 ident: B16-20250825 article-title: Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents publication-title: Am J Clin Nutr doi: 10.1093/ajcn/68.3.576 – volume: 91 start-page: 914 year: 2017 ident: B40-20250825 article-title: Acid retention with reduced glomerular filtration rate increases urine biomarkers of kidney and bone injury publication-title: Kidney Int doi: 10.1016/j.kint.2016.10.023 – reference: 36514414 - Kidney360. 2022 Nov 24;3(11):1819-1822 |
| SSID | ssj0002922836 |
| Score | 2.2620482 |
| Snippet | Visual Abstract
Key Points
Waist circumference and metabolic syndrome features were associated with greater risk of anion gap metabolic acidosis and its... Obesity is a recently identified risk factor for metabolic acidosis and anion gap elevations in the absence of CKD. Metabolic acidosis is a treatable condition... Waist circumference and metabolic syndrome features were associated with greater risk of anion gap metabolic acidosis and its components.Findings were... |
| SourceID | pubmedcentral proquest pubmed crossref wolterskluwer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1842 |
| SubjectTerms | Acid-Base Equilibrium Acidosis - epidemiology Adult Bicarbonates Humans Metabolic Syndrome - epidemiology Nutrition Surveys Obesity, Abdominal - epidemiology Original Investigation Renal Insufficiency, Chronic - epidemiology |
| Title | Associations of Metabolic Syndrome and Abdominal Obesity with Anion Gap Metabolic Acidosis among US Adults |
| URI | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&DO=10.34067/KID.0002402022 https://www.ncbi.nlm.nih.gov/pubmed/36514392 https://www.proquest.com/docview/2754502577 https://pubmed.ncbi.nlm.nih.gov/PMC9717647 |
| Volume | 3 |
| WOSCitedRecordID | wos000889087100007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Directory of Open Access Journals customDbUrl: eissn: 2641-7650 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002922836 issn: 2641-7650 databaseCode: DOA dateStart: 20200101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2641-7650 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0002922836 issn: 2641-7650 databaseCode: M~E dateStart: 20200101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6gdAkhEDcyqUyEg9IkC22Uzt-rLjTMSF1RX2LHCcRgS6p2m4MHhA_nWM7SRNGJXjgJYpysa18X0_P8bG_g9DjjCRg94G8MZExBChs6CmVpd5Qaz9QXGbcrib8eCiOjsLZTH7o9X7We2HO5qIowvNzufivUMM1ANtsnf0HuJtG4QKcA-hwBNjh-FfAtz64W-CSrgFoo2U9qdQJbMJgFCelK-hV1QZwU7KjwvDhtVq03hvpPCmNcImrTDSdPB0Z1Y5V27Ed50mRfmO8yX4cKlNqZN1y0jcTsuNqge07dZI3xJrMVV3g2gkabDJTS-gYRvfdbS6yBcqr6dlqvgJCXUI8t016P7V2DVww4gnu9GZrI8zaXCMtiwoRKP2TqWfgiZhs8_jtC6NBaZJEPu08CbAsTizIjBu30NXc-01du761gy5RMZRmUeD7H5tZOiqNPBB3mlC2y4Nuh3voSt1E17O5EK5cXHV79WtpVkSsvtgNES235vg6ulbFI3jkeHQD9dLiJvrc5hAuM9xwAdccwsAh3HAIVxzChkPYcggDh1rv1RzClkN4OsGOQ7fQ9NXL4-dvvKooh6dNitfjRtGOJoz6CY3DQFHN04ToMEyIH3NfMZUlJNSBkUXSIjYGP2MKvNZMUqVIzG6j3aIs0rsIUzVkvoY_FcV5IGMWhjJRNJEqVHFKYtFH-_UHjXSlWG8Kp8wjiFwtGBGAEW3A6KMnzQsLJ9ay_dFHNUIRGFSTJQPql6erCGgQDCESEND_HYdY01gNdR-JDpbNA0asvXunyD9Z0XYpiOABtPmsg3rktjtvG-a9rUO4j_Y2v64HaHe9PE0fosv6bJ2vlgO0I2bhwE4wDSyjfwGg273i |
| linkProvider | ISSN International Centre |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Associations+of+Metabolic+Syndrome+and+Abdominal+Obesity+with+Anion+Gap+Metabolic+Acidosis+among+US+Adults&rft.jtitle=Kidney360&rft.au=Lambert%2C+Douglas+C&rft.au=Kane%2C+Jamie&rft.au=Slaton%2C+Anthony&rft.au=Abramowitz%2C+Matthew+K&rft.date=2022-11-24&rft.eissn=2641-7650&rft.volume=3&rft.issue=11&rft.spage=1842&rft_id=info:doi/10.34067%2FKID.0002402022&rft_id=info%3Apmid%2F36514392&rft.externalDocID=36514392 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2641-7650&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2641-7650&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2641-7650&client=summon |