Evaluation of magnetic resonance spectroscopy total sodium concentration measures, and associations with microstructure and physical impairment in cervical myelopathy

Spinal cord injury causes a cascade of physiological responses, which may trigger a subsequent neurotoxic increase in intracellular sodium. This can lead to neurodegeneration, both at and beyond the site of injury, causing clinical symptoms and loss of function. However, in vivo measurements of tiss...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 7014 - 11
Main Authors:	Solanky, Bhavana S., Prados, Ferran, Tur, Carmen, Grussu, Francesco, Al-Ahmad, Selma, Yang, Xixi, Bianchi, Alessia, Kanber, Baris, Russo, Antonino, Russo, Vittorio, Choi, David, Panicker, Jalesh N., Wheeler-Kingshott, Claudia A. M. Gandini
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.02.2025 Nature Publishing Group Nature Portfolio
Subjects:	692/308/53 692/53/2423 Adult Aged ASIA score Case-Control Studies Central nervous system diseases Cervical Cord - diagnostic imaging Cervical Cord - metabolism Cervical Cord - pathology Cervical myelopathy Cervical Vertebrae Female Humanities and Social Sciences Humans Intracellular Macromolecular tissue volume Magnetic Resonance Imaging Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Male Middle Aged multidisciplinary Neurodegeneration Neurotoxicity NODDI Physiological responses Science Science (multidisciplinary) Sodium Sodium - analysis Sodium - metabolism Sodium MRS Spectroscopy Spectrum analysis Spinal cord Spinal Cord Diseases - diagnostic imaging Spinal Cord Diseases - metabolism Spinal Cord Diseases - pathology Spinal Cord Diseases - physiopathology Spinal cord injuries Spinal Cord Injuries - diagnostic imaging Spinal Cord Injuries - metabolism NODDI Sodium MRS Spinal cord Cervical myelopathy ASIA score Macromolecular tissue volume
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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