Evaluation of magnetic resonance spectroscopy total sodium concentration measures, and associations with microstructure and physical impairment in cervical myelopathy

Spinal cord injury causes a cascade of physiological responses, which may trigger a subsequent neurotoxic increase in intracellular sodium. This can lead to neurodegeneration, both at and beyond the site of injury, causing clinical symptoms and loss of function. However, in vivo measurements of tiss...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports Vol. 15; no. 1; pp. 7014 - 11
Main Authors: Solanky, Bhavana S., Prados, Ferran, Tur, Carmen, Grussu, Francesco, Al-Ahmad, Selma, Yang, Xixi, Bianchi, Alessia, Kanber, Baris, Russo, Antonino, Russo, Vittorio, Choi, David, Panicker, Jalesh N., Wheeler-Kingshott, Claudia A. M. Gandini
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 27.02.2025
Nature Publishing Group
Nature Portfolio
Subjects:
692/308/53
692/53/2423
Adult
Aged
ASIA score
Case-Control Studies
Central nervous system diseases
Cervical Cord - diagnostic imaging
Cervical Cord - metabolism
Cervical Cord - pathology
Cervical myelopathy
Cervical Vertebrae
Female
Humanities and Social Sciences
Humans
Intracellular
Macromolecular tissue volume
Magnetic Resonance Imaging
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Male
Middle Aged
multidisciplinary
Neurodegeneration
Neurotoxicity
NODDI
Physiological responses
Science
Science (multidisciplinary)
Sodium
Sodium - analysis
Sodium - metabolism
Sodium MRS
Spectroscopy
Spectrum analysis
Spinal cord
Spinal Cord Diseases - diagnostic imaging
Spinal Cord Diseases - metabolism
Spinal Cord Diseases - pathology
Spinal Cord Diseases - physiopathology
Spinal cord injuries
Spinal Cord Injuries - diagnostic imaging
Spinal Cord Injuries - metabolism
NODDI
Sodium MRS
Spinal cord
Cervical myelopathy
ASIA score
Macromolecular tissue volume
ISSN:2045-2322, 2045-2322
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spinal cord injury causes a cascade of physiological responses, which may trigger a subsequent neurotoxic increase in intracellular sodium. This can lead to neurodegeneration, both at and beyond the site of injury, causing clinical symptoms and loss of function. However, in vivo measurements of tissue sodium remain challenging. Here we utilise sodium magnetic resonance spectroscopy ( 23 Na-MRS) at 3T to measure tissue sodium concentration (TSC) and its association with microstructural measures and macromolecular MRI metrics in the cervical spinal cord, distal to the site of injury. Twenty people with cervical myelopathy and twenty healthy controls, were studied. Associations with motor and sensory impairments were explored using ASIA and jOAMEQ scores. No significant difference in TSC in the cervical myelopathy group (39 ± 10 mM) relative to healthy controls (35 ± 13 mM) was found. However, patients had a significantly lower cord-cross-sectional area than controls (70 ± 9 mm 2 vs. 82 ± 9 mm 2 , p  < 0.001). Lower-extremity function positively correlated with intracellular volume fraction ( p  = 0.031). In conclusion, using 23 Na-MRS, TSC in cervical myelopathy patients was successfully measured. Differences in TSC relative to healthy controls did not reach significance, despite a significant reduction in cord-cross-sectional area. However, lower intracellular volume fraction, indicating reduced neurite density distal to the site of injury, was associated with physical impairment.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-025-91658-w