Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells

In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.

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Vydáno v:Immunity (Cambridge, Mass.) Ročník 53; číslo 3; s. 476
Hlavní autoři: Effern, Maike, Hölzel, Michael
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 15.09.2020
Témata:
CD8-Positive T-Lymphocytes
Cell Differentiation
Glucocorticoids
Myeloid Cells
Tumor Microenvironment
ISSN:1097-4180, 1097-4180
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Shrnutí:In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:1097-4180
1097-4180
DOI:10.1016/j.immuni.2020.08.007