Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells

In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.

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Veröffentlicht in:Immunity (Cambridge, Mass.) Jg. 53; H. 3; S. 476
Hauptverfasser: Effern, Maike, Hölzel, Michael
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.09.2020
Schlagworte:
CD8-Positive T-Lymphocytes
Cell Differentiation
Glucocorticoids
Myeloid Cells
Tumor Microenvironment
ISSN:1097-4180, 1097-4180
Online-Zugang:Weitere Angaben
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Zusammenfassung:In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
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ISSN:1097-4180
1097-4180
DOI:10.1016/j.immuni.2020.08.007