Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells

In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.

Bibliographic Details

Published in:	Immunity (Cambridge, Mass.) Vol. 53; no. 3; p. 476
Main Authors:	Effern, Maike, Hölzel, Michael
Format:	Journal Article
Language:	English
Published:	United States 15.09.2020
Subjects:	CD8-Positive T-Lymphocytes Cell Differentiation Glucocorticoids Myeloid Cells Tumor Microenvironment
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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