Not Sweet: Glucocorticoids from Intratumoral Myeloid Cells Disable T Cells

In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Vol. 53; no. 3; p. 476
Main Authors: Effern, Maike, Hölzel, Michael
Format: Journal Article
Language:English
Published: United States 15.09.2020
Subjects:
CD8-Positive T-Lymphocytes
Cell Differentiation
Glucocorticoids
Myeloid Cells
Tumor Microenvironment
ISSN:1097-4180, 1097-4180
Online Access:Get more information
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Description
Summary:In this issue, Acharya et al. demonstrate that glucocorticoids produced by macrophages and monocytes in the tumor microenvironment induce a dysfunctional CD8 T cell phenotype. Blocking myeloid glucocorticogenesis enhances tumor immune surveillance and responsiveness to immune checkpoint therapy.
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ISSN:1097-4180
1097-4180
DOI:10.1016/j.immuni.2020.08.007