Dietary Factors Associated with Plasma Thyroid Peroxidase and Thyroglobulin Antibodies

The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enroll...

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Bibliographic Details
Published in:Nutrients Vol. 9; no. 11; p. 1186
Main Authors: Matana, Antonela, Torlak, Vesela, Brdar, Dubravka, Popović, Marijana, Lozić, Bernarda, Barbalić, Maja, Perica, Vesna Boraska, Punda, Ante, Polašek, Ozren, Hayward, Caroline, Zemunik, Tatijana
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 28.10.2017
MDPI
Subjects:
Adult
Aged
animal fats and oils
Antibodies
Autoantibodies - blood
Autoantigens - immunology
Autoimmune Diseases - blood
Autoimmune Diseases - immunology
Autoimmune Diseases - prevention & control
Biomarkers - blood
butter
Case-Control Studies
Chi-Square Distribution
Croatia
Cross-Sectional Studies
Diet - adverse effects
dried fruit
eating habits
Feeding Behavior
Female
food frequency questionnaires
food intake
Humans
Immunoglobulins
iodide peroxidase
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Logistic Models
Male
Metabolic disorders
Middle Aged
nuts
Odds Ratio
Plasma
Principal Component Analysis
Principal components analysis
Protective Factors
regression analysis
Risk Factors
thyroglobulin
Thyroglobulin - immunology
thyroid diseases
Thyroid Diseases - blood
Thyroid Diseases - immunology
Thyroid Diseases - prevention & control
Thyroid gland
Up-Regulation
vegetables
Croatia
thyroid peroxidase antibodies
autoimmune thyroid diseases
dietary habits
thyroglobulin antibodies
ISSN:2072-6643, 2072-6643
Online Access:Get full text
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Summary:The knowledge about dietary habits and their influence in the development of autoimmune thyroid disease is insufficient. The aim of this study was to analyse the association of dietary factors and plasma thyroid peroxidase antibodies (TPO-Ab) and/or thyroglobulin antibodies (Tg-Ab). The study enrolled 1887 participants originating from the South Croatia. Participants with elevated plasma TPO-Ab and/or Tg-Ab were defined as cases (n = 462) and those with TPO-Ab and/or Tg-Ab within referent values were defined as controls (n = 1425). Dietary intake was evaluated according to a food frequency questionnaire containing 58 food items. Principal component analysis was used to group food items into dietary groups. We used logistic regression analysis to examine dietary groups associated with positive plasma TPO-Ab and/or Tg-Ab. The results indicate that the dietary group with frequent consumption of animal fats and butter is associated with positive plasma TPO-Ab and/or Tg-Ab (p = 0.01). The dietary group with frequent consumption of vegetables as well as the dietary group with high consumption of dried fruit, nuts, and muesli are associated with negative findings of TPO-Ab and/or Tg-Ab (p = 0.048 and p = 0.02, respectively). We showed that the anti-inflammatory dietary groups are associated with the negative findings of plasma TPO-Ab and/or Tg-Ab.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu9111186