Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly...

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Bibliographic Details
Published in:	Neuron (Cambridge, Mass.) Vol. 109; no. 7; p. 1080
Main Authors:	Ramos, Daniel M, Skarnes, William C, Singleton, Andrew B, Cookson, Mark R, Ward, Michael E
Format:	Journal Article
Language:	English
Published:	United States 07.04.2021
Subjects:	Alzheimer Disease - therapy Genetic Engineering - methods Humans Induced Pluripotent Stem Cells - transplantation Neural Stem Cells - transplantation Neurodegenerative Diseases - genetics Neurodegenerative Diseases - therapy Stem Cell Research Stem Cell Transplantation
ISSN:	1097-4199, 1097-4199
Online Access:	Get more information
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Summary:	The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-4199 1097-4199
DOI:	10.1016/j.neuron.2021.03.022