Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly...

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Vydáno v:Neuron (Cambridge, Mass.) Ročník 109; číslo 7; s. 1080
Hlavní autoři: Ramos, Daniel M, Skarnes, William C, Singleton, Andrew B, Cookson, Mark R, Ward, Michael E
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 07.04.2021
Témata:
Alzheimer Disease - therapy
Genetic Engineering - methods
Humans
Induced Pluripotent Stem Cells - transplantation
Neural Stem Cells - transplantation
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - therapy
Stem Cell Research
Stem Cell Transplantation
ISSN:1097-4199, 1097-4199
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Shrnutí:The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2021.03.022