Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly...

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Published in:Neuron (Cambridge, Mass.) Vol. 109; no. 7; p. 1080
Main Authors: Ramos, Daniel M, Skarnes, William C, Singleton, Andrew B, Cookson, Mark R, Ward, Michael E
Format: Journal Article
Language:English
Published: United States 07.04.2021
Subjects:
Alzheimer Disease - therapy
Genetic Engineering - methods
Humans
Induced Pluripotent Stem Cells - transplantation
Neural Stem Cells - transplantation
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - therapy
Stem Cell Research
Stem Cell Transplantation
ISSN:1097-4199, 1097-4199
Online Access:Get more information
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Abstract The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
AbstractList The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.
Author Singleton, Andrew B
Ward, Michael E
Skarnes, William C
Cookson, Mark R
Ramos, Daniel M
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  surname: Ramos
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  givenname: William C
  surname: Skarnes
  fullname: Skarnes, William C
  organization: The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA
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  givenname: Andrew B
  surname: Singleton
  fullname: Singleton, Andrew B
  organization: Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA; Lab of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
– sequence: 4
  givenname: Mark R
  surname: Cookson
  fullname: Cookson, Mark R
  email: cookson@mail.nih.gov
  organization: Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA; Lab of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: cookson@mail.nih.gov
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  givenname: Michael E
  surname: Ward
  fullname: Ward, Michael E
  email: wardme@nih.gov
  organization: Center for Alzheimer's Disease and Related Dementias, National Institutes of Health, Bethesda, MD, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: wardme@nih.gov
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Snippet The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated...
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SubjectTerms Alzheimer Disease - therapy
Genetic Engineering - methods
Humans
Induced Pluripotent Stem Cells - transplantation
Neural Stem Cells - transplantation
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - therapy
Stem Cell Research
Stem Cell Transplantation
Title Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH
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