Self-reported pregnancy exposures and placental DNA methylation in the MARBLES prospective autism sibling study

Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by...

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Vydáno v:Environmental epigenetics Ročník 2; číslo 4; s. dvw024
Hlavní autoři: Schmidt, Rebecca J., Schroeder, Diane I., Crary-Dooley, Florence K., Barkoski, Jacqueline M., Tancredi, Daniel J., Walker, Cheryl K., Ozonoff, Sally, Hertz-Picciotto, Irva, LaSalle, Janine M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Oxford University Press 01.12.2016
Témata:
Autism
Birth weight
Body mass index
Body size
Children
Deoxyribonucleic acid
DNA
DNA methylation
Environmental factors
Epigenetics
Exposure
Fetuses
Folic acid
Gestational age
Pesticides
Placenta
Prediction models
Pregnancy
Robustness
Sequences
Shampoos
Siblings
Soaps
autism spectrum disorders
high-risk cohort
environmental factors
pesticides
pregnancy
placenta DNA methylation
ISSN:2058-5888, 2058-5888
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Shrnutí:Human placenta is a fetal-derived tissue that offers a unique sample of epigenetic and environmental exposures present in utero. In the MARBLES prospective pregnancy study of high-risk younger siblings of children with autism spectrum disorder (ASD), pregnancy and environmental factors collected by maternal interviews were examined as predictors of placental DNA methylation, including partially methylated domains (PMDs), an embryonic feature of the placental methylome. DNA methylation data from MethylC-seq analysis of 47 placentas of children clinically diagnosed at 3 years with ASD or typical development using standardized assessments were examined in relation to: child’s gestational age, birthweight, and diagnosis; maternal pre-pregnancy body mass index, smoking, education, parity, height, prenatal vitamin and folate intake; home ownership; pesticides professionally applied to lawns or gardens or inside homes, pet flea/tick pouches, collars, or soaps/shampoos used in the 3 months prior to or during pregnancy. Sequencing run, order, and coverage, and child race and sex were considered as potential confounders. Akaike information criterion was used to select the most parsimonious among candidate models. Final prediction models used sandwich estimators to produce homoscadisticity-robust estimates of the 95% confidence interval (CI) and P-values controlled the false discovery rate at 5%. The strongest, most robust associations were between pesticides professionally applied outside the home and higher average methylation over PMDs [0.45 (95% CI 0.17, 0.72), P = 0.03] and a reduced proportion of the genome in PMDs [−0.42 (95% CI − 0.67 to − 0.17), P = 0.03]. Pesticide exposures could alter placental DNA methylation more than other factors.
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ISSN:2058-5888
2058-5888
DOI:10.1093/eep/dvw024