Recent abacavir use and incident cardiovascular disease in contemporary-treated people with HIV

Assessing whether the previously reported association between abacavir (ABC) and cardiovascular disease (CVD) remained amongst contemporarily treated people with HIV. Multinational cohort collaboration. RESPOND participants were followed from the latest of 1 January 2012 or cohort enrolment until th...

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Published in:AIDS (London) Vol. 37; no. 3; p. 467
Main Authors: Jaschinski, Nadine, Greenberg, Lauren, Neesgaard, Bastian, Miró, Jose M, Grabmeier-Pfistershammer, Katharina, Wandeler, Gilles, Smith, Colette, De Wit, Stéphane, Wit, Ferdinand, Pelchen-Matthews, Annegret, Mussini, Cristina, Castagna, Antonella, Pradier, Christian, d'Arminio Monforte, Antonella, Vehreschild, Jörg, Sönnerborg, Anders, Anne, Alain V, Carr, Andrew, Bansi-Matharu, Loveleen, Lundgren, Jens, Garges, Harmony, Rogatto, Felipe, Zangerle, Robert, Günthard, Huldrych F, Rasmussen, Line D, Nescoi, Coca, Van Der Valk, Marc, Menozzi, Marianna, Muccini, Camilla, Mocroft, Amanda, Peters, Lars, Ryom, Lene
Format: Journal Article
Language:English
Published: England 01.03.2023
Subjects:
Cardiovascular Diseases - chemically induced
Cardiovascular Diseases - epidemiology
Disease Progression
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
Humans
Renal Insufficiency, Chronic - complications
Risk Factors
ISSN:1473-5571, 1473-5571
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Summary:Assessing whether the previously reported association between abacavir (ABC) and cardiovascular disease (CVD) remained amongst contemporarily treated people with HIV. Multinational cohort collaboration. RESPOND participants were followed from the latest of 1 January 2012 or cohort enrolment until the first of a CVD event (myocardial infarction, stroke, invasive cardiovascular procedure), last follow-up or 31 December 2019. Logistic regression examined the odds of starting ABC by 5-year CVD or chronic kidney disease (CKD) D:A:D risk score. We assessed associations between recent ABC use (use within the past 6 months) and risk of CVD with negative binomial regression models, adjusted for potential confounders. Of 29 340 individuals, 34% recently used ABC. Compared with those at low estimated CVD and CKD risks, the odds of starting ABC were significantly higher among individuals at high CKD risk [odds ratio 1.12 (95% confidence interval = 1.04-1.21)] and significantly lower for individuals at moderate, high or very high CVD risk [0.80 (0.72-0.88), 0.75 (0.64-0.87), 0.71 (0.56-0.90), respectively]. During 6.2 years of median follow-up (interquartile range; 3.87-7.52), there were 748 CVD events (incidence rate 4.7 of 1000 persons-years of follow up (4.3-5.0)]. The adjusted CVD incidence rate ratio was higher for individuals with recent ABC use [1.40 (1.20-1.64)] compared with individuals without, consistent across sensitivity analyses. The association did not differ according to estimated CVD (interaction P  = 0.56) or CKD ( P  = 0.98) risk strata. Within RESPOND's contemporarily treated population, a significant association between CVD incidence and recent ABC use was confirmed and not explained by preferential ABC use in individuals at increased CVD or CKD risk.
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ISSN:1473-5571
1473-5571
DOI:10.1097/QAD.0000000000003373