Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metab...

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Vydáno v:Multiple sclerosis Ročník 21; číslo 11; s. 1414 - 1422
Hlavní autoři: Laursen, Julie H, Søndergaard, Helle Bach, Albrechtsen, Anders, Frikke-Schmidt, Ruth, Koch-Henriksen, Nils, Soelberg Sørensen, Per, Sellebjerg, Finn, Oturai, Annette
Médium: Journal Article
Jazyk:angličtina
Vydáno: London, England SAGE Publications 01.10.2015
Sage Publications Ltd
Témata:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Specimen Banks
Cross-Sectional Studies
Denmark
Environment
Female
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Multiple Sclerosis - blood
Multiple Sclerosis - etiology
Multiple Sclerosis - genetics
Polymorphism, Single Nucleotide
Vitamin D - analogs & derivatives
Vitamin D - blood
Young Adult
Multiple sclerosis
environment
genetics
25-hydroxyvitamin D
vitamin D
ISSN:1352-4585, 1477-0970, 1477-0970
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Abstract Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism. Objective: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients. Methods: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies). Results: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10−4). Season of blood sampling (p = 2.8 × 10−31), sex (p = 1.9 × 10−5), BMI (p = 2.3 × 10−5), vitamin supplements (p = 7.0 × 10−22), and fish intake (p = 0.02) also had significant effects on 25(OH)D. Conclusion: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.
AbstractList Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism. To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients. Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies). We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D. In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.
Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism. Objective: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients. Methods: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC -, CYP2R1 - and NADSYN1 -SNPs was performed by TaqMan allelic discrimination (Life Technologies). Results: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10-4 ). Season of blood sampling (p = 2.8 × 10-31 ), sex (p = 1.9 × 10-5 ), BMI (p = 2.3 × 10-5 ), vitamin supplements (p = 7.0 × 10-22 ), and fish intake (p = 0.02) also had significant effects on 25(OH)D. Conclusion: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.
Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.BACKGROUNDEvidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism.To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.OBJECTIVETo examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients.Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).METHODSBlood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies).We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D.RESULTSWe found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10(-4)). Season of blood sampling (p = 2.8 × 10(-31)), sex (p = 1.9 × 10(-5)), BMI (p = 2.3 × 10(-5)), vitamin supplements (p = 7.0 × 10(-22)), and fish intake (p = 0.02) also had significant effects on 25(OH)D.In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.CONCLUSIONIn this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.
Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism. Objective: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients. Methods: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies). Results: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10−4). Season of blood sampling (p = 2.8 × 10−31), sex (p = 1.9 × 10−5), BMI (p = 2.3 × 10−5), vitamin supplements (p = 7.0 × 10−22), and fish intake (p = 0.02) also had significant effects on 25(OH)D. Conclusion: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.
Author Albrechtsen, Anders
Koch-Henriksen, Nils
Frikke-Schmidt, Ruth
Søndergaard, Helle Bach
Sellebjerg, Finn
Oturai, Annette
Laursen, Julie H
Soelberg Sørensen, Per
Author_xml – sequence: 1
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  organization: Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark
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  givenname: Helle Bach
  surname: Søndergaard
  fullname: Søndergaard, Helle Bach
  organization: Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark
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  surname: Albrechtsen
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  organization: Centre of Bioinformatics, Faculty of Science, University of Copenhagen, Denmark
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  surname: Frikke-Schmidt
  fullname: Frikke-Schmidt, Ruth
  organization: Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark
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  surname: Koch-Henriksen
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  organization: Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark
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  givenname: Annette
  surname: Oturai
  fullname: Oturai, Annette
  organization: Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Danish Multiple Sclerosis Center, Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25533295$$D View this record in MEDLINE/PubMed
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Keywords Multiple sclerosis
environment
genetics
25-hydroxyvitamin D
vitamin D
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Snippet Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown...
Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant...
Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown...
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StartPage 1414
SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Biological Specimen Banks
Cross-Sectional Studies
Denmark
Environment
Female
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Multiple Sclerosis - blood
Multiple Sclerosis - etiology
Multiple Sclerosis - genetics
Polymorphism, Single Nucleotide
Vitamin D - analogs & derivatives
Vitamin D - blood
Young Adult
Title Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis
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