Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis

Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metab...

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Published in:Multiple sclerosis Vol. 21; no. 11; pp. 1414 - 1422
Main Authors: Laursen, Julie H, Søndergaard, Helle Bach, Albrechtsen, Anders, Frikke-Schmidt, Ruth, Koch-Henriksen, Nils, Soelberg Sørensen, Per, Sellebjerg, Finn, Oturai, Annette
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01.10.2015
Sage Publications Ltd
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological Specimen Banks
Cross-Sectional Studies
Denmark
Environment
Female
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Multiple Sclerosis - blood
Multiple Sclerosis - etiology
Multiple Sclerosis - genetics
Polymorphism, Single Nucleotide
Vitamin D - analogs & derivatives
Vitamin D - blood
Young Adult
Multiple sclerosis
environment
genetics
25-hydroxyvitamin D
vitamin D
ISSN:1352-4585, 1477-0970, 1477-0970
Online Access:Get full text
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Summary:Background: Evidence is accumulating supporting a beneficial effect of vitamin D in multiple sclerosis (MS). Genome-wide association studies (GWAS) have shown significant associations between 25-hydroxyvitamin D (25(OH)D) and single nucleotide polymorphisms (SNPs) in key genes in the vitamin D metabolism. Objective: To examine the association between 25(OH)D and six GWAS SNPs and environmental factors in 1497 MS patients. Methods: Blood samples and lifestyle questionnaires were collected between 2009 and 2012. Genotyping of GC-, CYP2R1- and NADSYN1-SNPs was performed by TaqMan allelic discrimination (Life Technologies). Results: We found significant associations between 25(OH)D and SNPs in GC (rs7041, p = 0.01 and rs2282679, p = 0.03) and CYP2R1 (rs10741657, p =1.8 × 10−4). Season of blood sampling (p = 2.8 × 10−31), sex (p = 1.9 × 10−5), BMI (p = 2.3 × 10−5), vitamin supplements (p = 7.0 × 10−22), and fish intake (p = 0.02) also had significant effects on 25(OH)D. Conclusion: In this cross-sectional study, we found significant effects of environmental factors and SNPs in GC and CYP2R1 on 25(OH)D in MS patients. Since 25(OH)D might have protective effects in MS, and vitamin D supply is a modifiable factor, it may be important to include this in the MS treatment regimen.
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ISSN:1352-4585
1477-0970
1477-0970
DOI:10.1177/1352458514563590