IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation

Type 2 immunity serves to resist parasitic helminths, venoms, and toxins, but the role and regulation of neutrophils during type 2 immune responses are controversial. Helminth models suggested a contribution of neutrophils to type 2 immunity, whereas neutrophils are associated with increased disease...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 144; no. 1; pp. 267 - 279.e4
Main Authors:	Impellizzieri, Daniela, Ridder, Frederike, Raeber, Miro E., Egholm, Cecilie, Woytschak, Janine, Kolios, Antonios G.A., Legler, Daniel F., Boyman, Onur
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.07.2019 Elsevier Limited
Subjects:	Allergies Allergy Animals Asthma Blood & organ donations Cell Movement - physiology Chemokine receptors Chemotaxis CXCR2 protein CXCR4 protein Cytokines Disease Extracellular Traps - physiology Flow cytometry Human subjects Humans Hypotheses IL-13 IL-4 IL-4 receptor Immune response Infections Inflammation Inflammatory diseases innate immunity Interleukin 13 Interleukin 4 Interleukin-13 - physiology Interleukin-4 - physiology Leukocyte migration Leukocytes (neutrophilic) Ligands Mice, Knockout neutrophil Neutrophils Neutrophils - physiology Peripheral blood Receptors, Interleukin-4 - genetics Allergy AD PMA IL-4 receptor IL-4 IL-13 neutrophil G-CSF MPO IL-4R STAT innate immunity inflammation pSTAT HD NET
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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