Protective role of dietary Spirulina platensis against diazinon-induced Oxidative damage in Nile tilapia; Oreochromis niloticus

•Diazinon induced oxidative damage in tilapia liver, kidney and gills.•Spirulina has antioxidant activities against diazinon-induced damage.•Diazinon induced serum biochemical alterations.•Spirulina protected against diazinon-induced toxicities. The current study was performed to investigate the ame...

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Vydáno v:Environmental toxicology and pharmacology Ročník 54; s. 99 - 104
Hlavní autoři: Abdelkhalek, Nevien K.M., Eissa, Ismail A.M., Ahmed, Eman, Kilany, Omnia E., El-Adl, Mohamed, Dawood, Mahmoud A.O., Hassan, Ahmed M., Abdel-Daim, Mohamed M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.09.2017
Elsevier Science Ltd
Témata:
Acute toxicity
Alanine
Alanine transaminase
Alanine Transaminase - metabolism
Albumin
Alkaline phosphatase
Alkaline Phosphatase - metabolism
Animals
Antioxidant
Antioxidants
Antioxidants - pharmacology
Aspartate Aminotransferases - metabolism
Aspartate transaminase
Biochemical markers
Biomarkers
Catalase
Catalase - metabolism
Cholesterol
Cichlids - metabolism
Creatinine
Creatinine - metabolism
Cyanobacteria
Damage
Diazinon
Diazinon - toxicity
Diet
Dietary supplements
Fish
Fungicides
Gills
Gills - drug effects
Gills - metabolism
Globulins
Glucose
Glutathione
Glutathione - metabolism
Glutathione peroxidase
Impact analysis
Insecticides
Insecticides - toxicity
Kidney - drug effects
Kidney - metabolism
Kidneys
Lipid peroxidation
Liver
Liver - drug effects
Liver - metabolism
Male
Malondialdehyde
Malondialdehyde - metabolism
Markers
Nile tilapia
Oreochromis niloticus
Organophosphate
Oxidative stress
Oxidative Stress - drug effects
Peroxidase
Peroxidation
Proteins
Serum albumin
Spirulina
Spirulina platensis
Studies
Superoxide dismutase
Superoxide Dismutase - metabolism
Tilapia
Toxicity
Transaminase
Urea
Urea - metabolism
Uric acid
Uric Acid - metabolism
Oxidative stress
Spirulina
Organophosphate
Nile tilapia
Antioxidant
Diazinon
ISSN:1382-6689, 1872-7077, 1872-7077
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Shrnutí:•Diazinon induced oxidative damage in tilapia liver, kidney and gills.•Spirulina has antioxidant activities against diazinon-induced damage.•Diazinon induced serum biochemical alterations.•Spirulina protected against diazinon-induced toxicities. The current study was performed to investigate the ameliorating effect of dietary supplementation of 0.5 and 1% Spiurolina platensis (SP) diet against the sub-acute toxicity of diazinon (DZN) 0.28mg/L in Nile tilapia. At the end of experiment after 28days, hepatic and renal damage markers (aspartate transaminase, alanine transaminase, alkaline phosphatase, urea, uric acid and creatinine), serum biochemical parameters (total proteins, albumin, cholesterol and glucose) and tissue antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione and malondialdehyde) were detesrmined. The results of the current study revealed significant improvement in hepatic and renal damage markers after SP supplementation in fish exposed to DZN toxicity. Moreover, SP improved serum biochemical markers through increasing serum albumin and globulins with a significant decrease in serum glucose and cholesterol. In addition, liver, kidneys and gills antioxidant status showed a significant improvement after SP supplemented to fish exposed to DZN where a significant increase in tissue antioxidant activity were observed with a significant decline in lipid peroxidation levels. It can be concluded that, SP supplementation attenuated the toxic effect of DZN toxicity in Nile tilapia through improving liver and kidney functions with a significant enhancement of tissue antioxidant status.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1382-6689
1872-7077
1872-7077
DOI:10.1016/j.etap.2017.07.002