Validation of an automatic reference region extraction for the quantification of [ 18 F]DPA-714 in dynamic brain PET studies

There is a great need for a non-invasive methodology enabling the quantification of translocator protein overexpression in PET clinical imaging. [ F]DPA-714 has emerged as a promising translocator protein radiotracer as it is fluorinated, highly specific and returned reliable quantification using ar...

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Vydané v:Journal of cerebral blood flow and metabolism Ročník 38; číslo 2; s. 333
Hlavní autori: García-Lorenzo, Daniel, Lavisse, Sonia, Leroy, Claire, Wimberley, Catriona, Bodini, Benedetta, Remy, Philippe, Veronese, Mattia, Turkheimer, Federico, Stankoff, Bruno, Bottlaender, Michel
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.02.2018
Predmet:
Adult
Algorithms
Automation
Brain - diagnostic imaging
Cerebellum - diagnostic imaging
Cluster Analysis
Female
Fluorine Radioisotopes
Gray Matter - diagnostic imaging
Healthy Volunteers
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Positron-Emission Tomography - methods
Positron-Emission Tomography - standards
Pyrazoles
Pyrimidines
Radiopharmaceuticals
Receptors, GABA - genetics
Reproducibility of Results
Inflammation
brain imaging and clinical trials
positron emission tomography
microglia
ISSN:1559-7016
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Popis
Shrnutí:There is a great need for a non-invasive methodology enabling the quantification of translocator protein overexpression in PET clinical imaging. [ F]DPA-714 has emerged as a promising translocator protein radiotracer as it is fluorinated, highly specific and returned reliable quantification using arterial input function. Cerebellum gray matter was proposed as reference region for simplified quantification; however, this method cannot be used when inflammation involves cerebellum. Here we adapted and validated a supervised clustering (supervised clustering algorithm (SCA)) for [ F]DPA-714 analysis. Fourteen healthy subjects genotyped for translocator protein underwent an [ F]DPA-714 PET, including 10 with metabolite-corrected arterial input function and three for a test-retest assessment. Two-tissue compartmental modelling provided [Formula: see text] estimates that were compared to either [Formula: see text] or [Formula: see text] generated by Logan analysis (using supervised clustering algorithm extracted reference region or cerebellum gray matter). The supervised clustering algorithm successfully extracted a pseudo-reference region with similar reliability using classes that were defined using either all subjects, or separated into HAB and MAB subjects. [Formula: see text], [Formula: see text] and [Formula: see text] were highly correlated (ICC of 0.91 ± 0.05) but [Formula: see text] were ∼26% higher and less variable than [Formula: see text]. Reproducibility was good with 5% variability in the test-retest study. The clustering technique for [ F]DPA-714 provides a simple, robust and reproducible technique that can be used for all neurological diseases.
ISSN:1559-7016
DOI:10.1177/0271678X17692599