Sensing mitochondrial DNA stress in cardiotoxicity

Cytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stre...

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Bibliographic Details

Published in:	Trends in endocrinology and metabolism Vol. 34; no. 11; pp. 688 - 690
Main Authors:	Ding, Yang-Nan, Tang, Xiaoqiang
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.11.2023
Subjects:	cardiotoxicity cGAS Endocrinology and Metabolism mtDNA Z-DNA ZBP1 ZBP1 cGAS cardiotoxicity mtDNA Z-DNA
ISSN:	1043-2760, 1879-3061, 1879-3061
Online Access:	Get full text
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