Global geno-proteomic analysis reveals cross-continental sequence conservation and druggable sites among influenza virus polymerases

•Polymorphism analyses reveal 12% and 6% conservation among viral polymerase nucleotide and protein sequences resp.•Identified 29 conserved nucleotide regions can potentially be targeted for inhibitor designing.•Polymerases have undergone purifying mutations over past 6 decades resulting in their st...

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Vydané v:	Antiviral research Ročník 112; s. 120 - 131
Hlavní autori:	Babar, Mustafeez Mujtaba, Zaidi, Najam-us-Sahar Sadaf, Tahir, Muhammad
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier B.V 01.12.2014 Elsevier
Predmet:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Computational Biology Conserved Sequence Drug targets Geotemporal sequence conservation Human viral diseases Infectious diseases Influenza polymerases Influenza protein druggability Influenza virus Medical sciences Orthomyxoviridae - enzymology Pharmacology. Drug treatments Phylogeography Protein Conformation RNA Replicase - chemistry RNA Replicase - genetics Sequence Analysis, DNA Sequence Analysis, Protein Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral Proteins - chemistry Viral Proteins - genetics Influenza protein druggability Influenza polymerases Geotemporal sequence conservation Drug targets Influenza virus Conservation Orthomyxoviridae Influenzavirus Protein Infection Virus Viral disease Analysis Influenza Targeted drug Proteomics
ISSN:	0166-3542, 1872-9096, 1872-9096
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