Whole genome sequencing of a rare rotavirus from archived stool sample demonstrates independent zoonotic origin of human G8P[14] strains in Hungary

•The genome sequence and phylogenetic analysis of a human G8P[14] rotavirus strain is described.•The strain originates very likely from an animal host species.•Different P[14] strains detected in Hungary likely represent independent zoonotic events. Genotype P[14] rotaviruses in humans are thought t...

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Published in:Virus research Vol. 227; pp. 96 - 103
Main Authors: Marton, Szilvia, Dóró, Renáta, Fehér, Enikő, Forró, Barbara, Ihász, Katalin, Varga-Kugler, Renáta, Farkas, Szilvia L., Bányai, Krisztián
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 02.01.2017
Subjects:
cattle
feces
Genetic diversity
genome
genotype
hosts
humans
Hungary
nucleotide sequences
Phylogenetic analysis
phylogeny
Reassortment
Reoviridae
risk
Rotavirus
Rotavirus A
sequence analysis
sheep
Viral zoonosis
Hungary
Phylogenetic analysis
Genetic diversity
Rotavirus A
Viral zoonosis
Reassortment
ISSN:0168-1702, 1872-7492
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Summary:•The genome sequence and phylogenetic analysis of a human G8P[14] rotavirus strain is described.•The strain originates very likely from an animal host species.•Different P[14] strains detected in Hungary likely represent independent zoonotic events. Genotype P[14] rotaviruses in humans are thought to be zoonotic strains originating from bovine or ovine host species. Over the past 30 years only few genotype P[14] strains were identified in Hungary totaling<0.1% of all human rotaviruses whose genotype had been determined. In this study we report the genome sequence and phylogenetic analysis of a human genotype G8P[14] strain, RVA/Human-wt/HUN/182-02/2001/G8P[14]. The whole genome constellation (G8-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3) of this strain was shared with another Hungarian zoonotic G8P[14] strain, RVA/Human-wt/HUN/BP1062/2004/G8P[14], although phylogenetic analyses revealed the two rotaviruses likely had different progenitors. Overall, our findings indicate that human G8P[14] rotavirus detected in Hungary in the past originated from independent zoonotic events. Further studies are needed to assess the public health risk associated with infections by various animal rotavirus strains.
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ISSN:0168-1702
1872-7492
DOI:10.1016/j.virusres.2016.09.012